Perspectives on the prevention and treatment of infection for orthopedic tissue engineering applications

被引：24

作者：

Shah, Sarita R. ^{[1
]}

Kurtis, Kasper F. ^{[1
]}

Mikos, Antonios G. ^{[1
,2
]}

机构：

[1] Rice Univ, Dept Bioengn, Houston, TX 77251 USA

[2] Rice Univ, Dept Chem & Biomol Engn, Houston, TX 77251 USA

来源：

CHINESE SCIENCE BULLETIN | 2013年 / 58卷 / 35期

关键词：

tissue engineering; infection; antibiotic delivery; antifouling agents; D-AMINO ACIDS; CONTROLLED-RELEASE; IN-VITRO; ANTIMICROBIAL PEPTIDES; ESCHERICHIA-COLI; DRUG-DELIVERY; ANTIBIOTICS; RESISTANCE; SILVER; GROWTH;

D O I：

10.1007/s11434-013-5780-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The emergence of orthopedic tissue engineering devices as viable clinical solutions demands that the field address significant clinical complications associated with the implantation of foreign materials in the body, especially infection. While tissue engineering has focused on the development of methods to regenerate and repair, until recently there has been a relative dearth of literature regarding the intersection of tissue engineering and infection. In particular, local delivery of antimicrobials has long been of clinical interest, but only recently has that been translated into the realm of tissue engineering. In this perspective, we briefly review major modes of local delivery for infection prevention and treatment and discuss possible strategies for preventing implant-associated infections.

引用

页码：4342 / 4348

页数：7

共 65 条

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