Petabyte-scale innovations at the European Nucleotide Archive

被引：58

作者：

Cochrane, Guy ^{[1
]}

Akhtar, Ruth ^{[1
]}

Bonfield, James ^{[2
]}

Bower, Lawrence ^{[1
]}

Demiralp, Fehmi ^{[1
]}

Faruque, Nadeem ^{[1
]}

Gibson, Richard ^{[1
]}

Hoad, Gemma ^{[1
]}

Hubbard, Tim ^{[2
]}

Hunter, Christopher ^{[1
]}

Jang, Mikyung ^{[1
]}

Juhos, Szilveszter ^{[1
]}

Leinonen, Rasko ^{[1
]}

Leonard, Steven ^{[2
]}

Lin, Quan ^{[1
]}

Lopez, Rodrigo ^{[1
]}

Lorenc, Dariusz ^{[1
]}

McWilliam, Hamish ^{[1
]}

Mukherjee, Gaurab ^{[1
]}

Plaister, Sheila ^{[1
]}

Radhakrishnan, Rajesh ^{[1
]}

Robinson, Stephen ^{[1
]}

Sobhany, Siamak ^{[1
]}

Hoopen, Petra Ten ^{[1
]}

Vaughan, Robert ^{[1
]}

Zalunin, Vadim ^{[1
]}

Birney, Ewan ^{[1
]}

机构：

[1] EMBL European Bioinformat Inst, Cambridge CB10 1SD, England

[2] Sanger Inst, Cambridge CB10 1SA, England

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

基金：

英国惠康基金;

关键词：

DATABASE; SEQUENCE;

D O I：

10.1093/nar/gkn765

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dramatic increases in the throughput of nucleotide sequencing machines, and the promise of ever greater performance, have thrust bioinformatics into the era of petabyte-scale data sets. Sequence repositories, which provide the feed for these data sets into the worldwide computational infrastructure, are challenged by the impact of these data volumes. The European Nucleotide Archive (ENA; http://www.ebi.ac.uk/embl), comprising the EMBL Nucleotide Sequence Database and the Ensembl Trace Archive, has identified challenges in the storage, movement, analysis, interpretation and visualization of petabyte-scale data sets. We present here our new repository for next generation sequence data, a brief summary of contents of the ENA and provide details of major developments to submission pipelines, high-throughput rule-based validation infrastructure and data integration approaches.

引用

页码：D19 / D25

页数：7

共 12 条

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