CYTOGENETIC DAMAGE IN TURKISH COKE OVEN WORKERS EXPOSE l TO POLYCYCLIC AROMATIC HYDROCARBONS: ASSOCIATION WITH CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, AND GSTP1 GENE POLYMORPHISMS

被引：6

作者：

Ada, Ahmet Oguz ^{[1
]}

Demiroglu, Canan ^{[2
]}

Yilmazer, Meltem ^{[2
]}

Suzen, Halit Sinan ^{[1
]}

Demirbag, Ali Eba ^{[3
]}

Efe, Sibel ^{[4
]}

Alemdar, Yilmaz ^{[4
]}

Iscan, Mumtaz ^{[1
]}

Burgaz, Sema ^{[2
]}

机构：

[1] Ankara Univ, Fac Pharm, Dept Toxicol, Tandogan, Turkey

[2] Gazi Univ, Dept Toxicol, Fac Pharm, Etiler, Turkey

[3] Yuksek Ihtisas Hosp, Gastrointestinal Surg Dept, Sihhiye, Turkey

[4] Eregli Iron & Steel Works Co, Karadeniz Eregli, Turkey

来源：

ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY | 2013年 / 64卷 / 03期

关键词：

chromosomal aberrations; biomarkers; micronuclei; occupational exposure; PERIPHERAL-BLOOD LYMPHOCYTES; CYTOKINESIS-BLOCK MICRONUCLEUS; MICROSOMAL EPOXIDE HYDROLASE; SISTER-CHROMATID EXCHANGES; OF-THE-LITERATURE; CANCER-RISK; CYTOCHROME-P450; 1A1; POPULATION; BIOMARKERS; FREQUENCY;

D O I：

10.2478/10004-1254-64-2013-2328

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The aim of this study was to determine the frequencies of chromosomal aberrations (CA) and cytochalasin-blocked micronuclei (CBMN) in peripheral blood lymphocytes from Turkish coke oven workers and the influence of CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms on these biomarkers. Cytogenetic analysis showed that occupational exposure significantly increased the CA and CBMN frequencies. Gene polymorphisms, on the other hand, did not affect CA or CBMN in either exposed or control subjects. However, due to the limited sample size, our findings need to be verified in future studies with a larger sample.

引用

页码：359 / 369

页数：11

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