Investigations on Bio-mineralization of reduced graphene oxide aerogel in the presence of various polymers

被引：6

作者：

Asha, S. ^{[1
]}

Kumar, G. Vanitha ^{[1
]}

Ananth, A. Nimrodh ^{[2
]}

Jose, Sujin P. ^{[3
]}

Rajan, M. A. Jothi ^{[1
]}

机构：

[1] Arul Anandar Coll, PG & Res Dept Phys, Bionano Lab, Madurai, Tamil Nadu, India

[2] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou, Zhejiang, Peoples R China

[3] Madurai Kamaraj Univ, Sch Phys, Madurai 625024, Tamil Nadu, India

来源：

MATERIALS TODAY-PROCEEDINGS | 2019年 / 9卷

关键词：

Reduced graphene oxide; biomineralization; polymers; simulated body fluid; hydroxyapatite; HYDROXYAPATITE; TISSUE;

D O I：

10.1016/j.matpr.2019.02.168

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Reduced graphene oxide (RGO) based light weight aerogel scaffolds were prepared using a simple hydrothermal method with ascorbic acid as a reducing agent. Hydroxyapatite was biomimetically mineralized on the surface of these scaffolds by soaking RGO aerogels in simulated body fluid which consists of calcium and phosphorous precursors. The biomimetic mineralization of these samples was also studied after functionalizing RGO aerogel with various biocompatible polymers such as collagen, chitosan and poly-L-glutamic acid. The influence of these polymers towards mineralization were studied using various characterization methods. It was observed that polymer functionalized RGO aerogel exhibited increased rate of mineralization due to the presence of more functional groups which aids in mineralization and growth of apatite. Thus, mineralized spherical apatite was found to be uniformly assembled on the surface and the interior of the aerogel. The electrical properties of these samples were studied using a source meter and the electrical conductivity of these samples varied depending upon the functionalized polymers. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：389 / 396

页数：8

共 17 条

[1] Asha S., 2015, J GREEN SCI TECHNOL, V2, P49, DOI [10.1166/jgst.2015.1040, DOI 10.1166/JGST.2015.1040]
[2] Mechanical properties and biomedical applications of a nanotube hydroxyapatite-reduced graphene oxide composite
Baradaran, S.
Moghaddam, E.
Basirun, W. J.
Mehrali, M.
Sookhakian, M.
Hamdi, M.
Moghaddam, M. R. Nakhaei
Alias, Y.
[J]. CARBON, 2014, 69 : 32 - 45
[3] Proteins and Their Peptide Motifs in Acellular Apatite Mineralization of Scaffolds for Tissue Engineering
Benesch, Johan
Mano, Joao F.
Reis, Rui L.
[J]. TISSUE ENGINEERING PART B-REVIEWS, 2008, 14 (04) : 433 - 445
[4] FT-IR study for hydroxyapatite/collagen nanocomposite cross-linked by glutaraldehyde
Chang, MC
Tanaka, J
[J]. BIOMATERIALS, 2002, 23 (24) : 4811 - 4818
[5] Hierarchical porous materials for tissue engineering
Jones, JR
Lee, PD
Hench, LL
[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2006, 364 (1838): : 263 - 281
[6] How useful is SBF in predicting in vivo bone bioactivity?
Kokubo, T
Takadama, H
[J]. BIOMATERIALS, 2006, 27 (15) : 2907 - 2915
[7] In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide
Li, Ming
Wang, Yanbo
Liu, Qian
Li, Qiuhong
Cheng, Yan
Zheng, Yufeng
Xi, Tingfei
Wei, Shicheng
[J]. JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (04) : 475 - 484
[8] Gelatin functionalized graphene oxide for mineralization of hydroxyapatite: biomimetic and in vitro evaluation
Liu, Hongyan
Cheng, Ju
Chen, Fengjuan
Bai, Decheng
Shao, Changwei
Wang, Jun
Xi, Pinxian
Zeng, Zhengzhi
[J]. NANOSCALE, 2014, 6 (10) : 5315 - 5322
[9] Freeze-drying synthesis, characterization and in vitro bioactivity of chitosan/graphene oxide/hydroxyapatite nanocomposite
Mohandes, F.
Salavati-Niasari, M.
[J]. RSC ADVANCES, 2014, 4 (49) : 25993 - 26001
[10] Synthetic bone graft substitutes
Moore, WR
Graves, SE
Bain, GI
[J]. ANZ JOURNAL OF SURGERY, 2001, 71 (06) : 354 - 361

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