An unexpected connection: Lymph node lymphangiogenesis and dendritic cell migration

被引：17
作者：
Halin, C [1 ]
Detmar, M [1 ]
机构：
[1] ETH, Swiss Fed Inst Technol, Inst Pharmaceut Sci, CH-8093 Zurich, Switzerland
来源：
IMMUNITY | 2006年 / 24卷 / 02期
关键词：
D O I：
10.1016/j.immuni.2006.01.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Migration of antigen-presenting dendritic cells (DCs) through lymphatics to draining lymph nodes (LNs) represents a key step in the initiation of an adaptive immune response. In this issue of Immunity, Angeli et al. (2006) provide the first evidence that remodeling of the lymphatic network within LNs and in peripheral tissues enhances DC migration after immunization and that this process depends on the presence of B cells within the LN.
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收藏
页码：129 / 131
页数：3
相关论文
共 10 条
  • [1] Lymphangiogenesis in development and human disease
    Alitalo, K
    Tammela, T
    Petrova, TV
    [J]. NATURE, 2005, 438 (7070) : 946 - 953
  • [2] Berger TG, 2003, CURR TOP MICROBIOL, V276, P163
  • [3] VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment
    Cursiefen, C
    Chen, L
    Borges, LP
    Jackson, D
    Cao, JT
    Radziejewski, C
    D'Amore, PA
    Dana, MR
    Wiegand, SJ
    Streilein, JW
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (07) : 1040 - 1050
  • [4] In vivo imaging of lymphocyte trafficking
    Halin, C
    Mora, JR
    Sumen, C
    von Andrian, UH
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2005, 21 : 581 - 603
  • [5] VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
    Hirakawa, S
    Kodama, S
    Kunstfeld, R
    Kajiya, K
    Brown, LF
    Detmar, M
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (07) : 1089 - 1099
  • [6] Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates
    Kerjaschki, D
    Regele, HM
    Moosberger, I
    Nagy-Bojarski, K
    Watschinger, B
    Soleiman, A
    Birner, P
    Krieger, S
    Hovorka, A
    Silberhumer, G
    Laakkonen, P
    Petrova, T
    Langer, B
    Raab, I
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (03): : 603 - 612
  • [7] Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia
    Kunstfeld, R
    Hirakawa, S
    Hong, YK
    Schacht, V
    Lange-Asschenfeldt, B
    Velasco, P
    Lin, C
    Fiebiger, E
    Wei, XB
    Wu, Y
    Hicklin, D
    Bohlen, P
    Detmar, M
    [J]. BLOOD, 2004, 104 (04) : 1048 - 1057
  • [8] Inflammation-induced lymphangiogenesis in the cornea arises from CD11 b-positive macrophages
    Maruyama, K
    Li, M
    Cursiefen, C
    Jackson, DG
    Keino, H
    Tomita, M
    Van Rooijen, N
    Takenaka, H
    D'Amore, PA
    Stein-Streilein, J
    Losordo, DW
    Streilein, JW
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (09) : 2363 - 2372
  • [9] The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature
    Oliver, G
    Detmar, M
    [J]. GENES & DEVELOPMENT, 2002, 16 (07) : 773 - 783
  • [10] Dendritic-cell trafficking to lymph nodes through lymphatic vessels
    Randolph, GJ
    Angeli, V
    Swartz, MA
    [J]. NATURE REVIEWS IMMUNOLOGY, 2005, 5 (08) : 617 - 628
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