Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting

被引：19

作者：

Buettner, Ralf ^{[1
]}

Morales, Corey ^{[1
]}

Caserta, Enrico ^{[1
]}

Troadec, Estelle ^{[1
]}

Gunes, Emine G. ^{[1
]}

Viola, Domenico ^{[1
]}

Khalife, Jihane ^{[1
]}

Li, Hongzhi ^{[2
]}

Keats, Jonathan J. ^{[3
]}

Christofferson, Austin ^{[3
]}

Wu, Xiwei ^{[4
]}

Synold, Timothy W. ^{[5
]}

Palmer, Joycelynne ^{[2
]}

Sanchez, James F. ^{[1
]}

Pozhitkov, Alexander ^{[2
]}

Vaidehi, Nagarajan ^{[2
]}

Marcucci, Guido ^{[6
]}

Krishnan, Amrita ^{[1
]}

Rosenzweig, Michael A. ^{[1
]}

Pichiorri, Flavia ^{[1
]}

Rosen, Steven T. ^{[1
]}

机构：

[1] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Judy & Bernard Briskin Ctr Multiple Myeloma Res, Hematol Malignancies & Stem Cell Transplantat Ins, 1500 E Duarte Rd, Duarte, CA 91010 USA

[2] City Hope Natl Med Ctr, Dept Computat & Quantitat Med, Duarte, CA USA

[3] Translat Genom Res Inst, Integrated Canc Genom, Phoenix, AZ USA

[4] City Hope Natl Med Ctr, Beckman Res Inst, Dept Mol Med, Integrat Genom Core, Duarte, CA USA

[5] City Hope Natl Med Ctr, Beckman Res Inst, Dept Canc Biol, Duarte, CA USA

[6] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Gehr Family Ctr Leukemia Res, Hematol Malignancies & Stem Cell Transplantat Ins, Duarte, CA USA

来源：

BLOOD ADVANCES | 2019年 / 3卷 / 07期

基金：

美国国家卫生研究院;

关键词：

MULTIPLE-MYELOMA; KINASE INHIBITOR; IDENTIFICATION; ACTIVATION; PROMOTES; DRUG;

D O I：

10.1182/bloodadvances.2018027227

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：1027 / 1032

页数：6

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