Identification of specific pre-analytical quality control markers in plasma and serum samples

被引:9
|
作者
Ruiz-Godoy, Luz [1 ]
Enriquez-Carcamo, Virginia [1 ]
Suarez-Roa, Lourdes [1 ]
Lourdes Lopez-Castro, Maria [1 ]
Santamaria, Abel [2 ]
Orozco-Morales, Mario [3 ,4 ]
Laura Colin-Gonzalez, Ana [1 ]
机构
[1] Inst Nacl Cancerol, Banco Tumores, SSA San Fernando 22 Col,Secc 16, Mexico City 14080, DF, Mexico
[2] Inst Nacl Neurol & Neurocirug, Lab Aminoacidos Excitadores, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico
[3] Inst Nacl Cancerol, Unidad Funct Oncol Torac, Mexico City 14080, DF, Mexico
[4] Inst Nacl Cancerol, Lab Med Personalizada, Mexico City 14080, DF, Mexico
关键词
FREEZE-THAW CYCLES; WHOLE-BLOOD; LACTATE-DEHYDROGENASE; STORAGE TEMPERATURES; DELAYED SEPARATION; STABILITY; BIOBANK; TIME; ANALYTES; IMPACT;
D O I
10.1039/c9ay00131j
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Blood is a liquid connective tissue with a complex composition that supplies oxygen and nutrients to cells. It is minimally invasive to obtain and can be used in "omics" technologies. Current research regarding blood-based biomarkers has gained considerable attention as a useful tool for diagnostic, therapeutic, and drug development; however, several research groups have reported controversial results despite using the same analytical platform. Such discrepancy can be caused by errors made during the pre-analytical phase. Therefore, quality control of pre-analytical variables is an important factor that could affect the reproducibility and credibility of results. This review discusses the challenge to identify blood quality control markers and describes several molecules that could be potential candidates.
引用
收藏
页码:2259 / 2271
页数:13
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