New indications and controversies in arginine therapy

被引：66
作者：
Coman, David [1 ]
Yaplito-Lee, Joy [1 ]
Boneh, Avihu [1 ,2 ]
机构：
[1] Royal Childrens Hosp, Metab Serv, Genet Hlth Serv Vic, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia
[2] Univ Melbourne, Dept Paediat, Melbourne, Vic 3010, Australia
来源：
CLINICAL NUTRITION | 2008年 / 27卷 / 04期
关键词：
arginine; citrulline; urea cycle; nitric oxide; creatine; MELAS; glutaric aciduria type I; asthma;
D O I：
10.1016/j.clnu.2008.05.007
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Arginine is an important, versatile and a conditionally essential amino acid. Besides serving as a building block for tissue proteins, arginine plays a critical role in ammonia detoxification, and nitric oxide and creatine production. Arginine supplementation is an essential component for the treatment of urea cycle defects but recently some reservations have been raised with regards to the doses used in the treatment regimens of these disorders. In recent years, arginine supplementation or restriction has been proposed and trialled in several disorders, including vascular diseases and asthma, mitochondrial encephalopathy Lactic acidosis and stroke-like episodes (MELAS), glutaric aciduria typed I and disorders of creatine metabolism, both production and transportation into the central nervous system. Herein we present new therapeutic indications and controversies surrounding arginine supplementation or deprivation. (C) 2008 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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收藏
页码：489 / 496
页数：8
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