Cis-acting noncoding RNAs: friends and foes

被引：295
作者：
Guil, Sonia [1 ]
Esteller, Manel [1 ,2 ,3 ]
机构：
[1] Bellvitge Biomed Res Inst, Canc Epigenet & Biol Program, Barcelona, Catalonia, Spain
[2] Univ Barcelona, Sch Med, Dept Physiol Sci 2, Barcelona, Catalonia, Spain
[3] Inst Catalana Recerca & Estudis Avancats, Barcelona, Catalonia, Spain
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 11期
基金：
欧洲研究理事会;
关键词：
NATURAL ANTISENSE TRANSCRIPT; GENE-EXPRESSION; BIDIRECTIONAL PROMOTERS; POLYCOMB CBX7; CHROMATIN; GENOME; IDENTIFICATION; METHYLATION; MECHANISMS; ENHANCERS;
D O I：
10.1038/nsmb.2428
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In recent years, the number and types of known functional noncoding RNAs have increased considerably. A subset of both short- and long-sized species are known to be involved in the cis regulation of target genes located at or near the same genomic locus. Their expression is often coordinated with that of neighboring protein-coding genes, and in many cases, related transcripts can influence each other at one step or another during their biogenesis. Here, we review the current literature, summarizing the existing knowledge about mammalian cis-acting RNAs and their impact on physiological and disease states.
引用
收藏
页码：1068 / 1075
页数：8
相关论文
共 102 条
  • [21] The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator
    Feng, Jianchi
    Bi, Chumming
    Clark, Brian S.
    Mady, Rina
    Shah, Palak
    Kohtz, Jhumku D.
    [J]. GENES & DEVELOPMENT, 2006, 20 (11) : 1470 - 1484
  • [22] Genomic imprinting: the emergence of an epigenetic paradigm
    Ferguson-Smith, Anne C.
    [J]. NATURE REVIEWS GENETICS, 2011, 12 (08) : 565 - 575
  • [23] Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome
    Flynn, Ryan A.
    Almada, Albert E.
    Zamudio, Jesse R.
    Sharp, Phillip A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (26) : 10460 - 10465
  • [24] Sense-antisense pairs in mammals: functional and evolutionary considerations
    Galante, Pedro A. F.
    Vidal, Daniel O.
    de Souza, Jorge E.
    Camargo, Anamaria A.
    de Souza, Sandro J.
    [J]. GENOME BIOLOGY, 2007, 8 (03)
  • [25] Polycomb CBX7 has a unifying role in cellular lifespan
    Gil, J
    Bernard, D
    Martínez, D
    Beach, D
    [J]. NATURE CELL BIOLOGY, 2004, 6 (01) : 67 - U19
  • [26] Regulation of the INK4b-ARF-INK4a tumour suppressor locus:: all for one or one for all
    Gil, Jesus
    Peters, Gordon
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (09) : 667 - 677
  • [27] R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters
    Ginno, Paul A.
    Lott, Paul L.
    Christensen, Holly C.
    Korf, Ian
    Chedin, Frederic
    [J]. MOLECULAR CELL, 2012, 45 (06) : 814 - 825
  • [28] Intronic RNAs mediate EZH2 regulation of epigenetic targets
    Guil, Sonia
    Soler, Marta
    Portela, Anna
    Carrere, Jordi
    Fonalleras, Elena
    Gomez, Antonio
    Villanueva, Alberto
    Esteller, Manel
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (07) : 664 - +
  • [29] Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    Gupta, Rajnish A.
    Shah, Nilay
    Wang, Kevin C.
    Kim, Jeewon
    Horlings, Hugo M.
    Wong, David J.
    Tsai, Miao-Chih
    Hung, Tiffany
    Argani, Pedram
    Rinn, John L.
    Wang, Yulei
    Brzoska, Pius
    Kong, Benjamin
    Li, Rui
    West, Robert B.
    van de Vijver, Marc J.
    Sukumar, Saraswati
    Chang, Howard Y.
    [J]. NATURE, 2010, 464 (7291) : 1071 - U148
  • [30] Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
    Guttman, Mitchell
    Amit, Ido
    Garber, Manuel
    French, Courtney
    Lin, Michael F.
    Feldser, David
    Huarte, Maite
    Zuk, Or
    Carey, Bryce W.
    Cassady, John P.
    Cabili, Moran N.
    Jaenisch, Rudolf
    Mikkelsen, Tarjei S.
    Jacks, Tyler
    Hacohen, Nir
    Bernstein, Bradley E.
    Kellis, Manolis
    Regev, Aviv
    Rinn, John L.
    Lander, Eric S.
    [J]. NATURE, 2009, 458 (7235) : 223 - 227
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