Analysis of Variola and Vaccinia Virus Neutralization Assays for Smallpox Vaccines

被引：16

作者：

Hughes, Christine M. ^{[1
]}

Newman, Frances K. ^{[2
]}

Davidson, Whitni B. ^{[1
]}

Olson, Victoria A. ^{[1
]}

Smith, Scott K. ^{[1
]}

Holman, Robert C. ^{[1
]}

Yan, Lihan ^{[3
]}

Frey, Sharon E. ^{[2
]}

Belshe, Robert B. ^{[2
]}

Karem, Kevin L. ^{[1
]}

Damon, Inger K. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA

[2] St Louis Univ, Sch Med, Div Infect Dis & Immunol, Edward A Doisy Res Ctr, St Louis, MO USA

[3] EMMES Corp, Rockville, MD USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2012年 / 19卷 / 07期

基金：

美国国家卫生研究院;

关键词：

RESPONSES;

D O I：

10.1128/CVI.00056-12

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Possible smallpox reemergence drives research for third-generation vaccines that effectively neutralize variola virus. A comparison of neutralization assays using different substrates, variola and vaccinia (Dryvax and modified vaccinia Ankara [MVA]), showed significantly different 90% neutralization titers; Dryvax underestimated while MVA overestimated variola neutralization. Third-generation vaccines may rely upon neutralization as a correlate of protection.

引用

页码：1116 / 1118

页数：3

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