Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

被引：210

作者：

Frazier, Kendall S. ^{[1
]}

Seely, John Curtis ^{[2
]}

Hard, Gordon C.

Betton, Graham ^{[3
]}

Burnett, Roger ^{[4
]}

Nakatsuji, Shunji ^{[5
]}

Nishikawa, Akiyoshi ^{[6
]}

Durchfeld-Meyer, Beate ^{[7
]}

Bube, Axel ^{[7
]}

机构：

[1] GlaxoSmithKline, Safety Assessment, 709 Swedeland Rd,UE0376,POB 1539, King Of Prussia, PA 19406 USA

[2] EPL Inc, Res Triangle Pk, NC USA

[3] Betton ToxPath Consulting LLP, Macclesfield, Cheshire, England

[4] TAS Valley Consultancy, Tasburgh, England

[5] Astellas Pharma Inc, Drug Safety Res Labs, Osaka, Japan

[6] Natl Inst Hlth Sci, Tokyo, Japan

[7] Sanofi Aventis, Hattersheim, Germany

来源：

TOXICOLOGIC PATHOLOGY | 2012年 / 40卷 / 04期

关键词：

urinary system; preclinical safety-assessment/risk management; rat pathology; mouse pathology; CHRONIC PROGRESSIVE NEPHROPATHY; RENAL PAPILLARY NECROSIS; SPRAGUE-DAWLEY RAT; NEPHROBLASTOMA WILMS-TUMOR; UPPER UROTHELIAL CARCINOMA; POLYCYSTIC KIDNEY-DISEASE; ANGIOTENSIN-II ANTAGONIST; DISTAL CONVOLUTED TUBULE; MESSENGER-RNA EXPRESSION; MALE F344 RATS;

D O I：

10.1177/0192623312438736

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying lesions observed in the urinary tract of rats and mice. The standardized nomenclature of urinary tract lesions presented in this document is also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous developmental and aging lesions as well as those induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for urinary tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

引用

页码：14 / 86

页数：73

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