Bioinspired Non-Heme Iron Complexes: The Evolution of Facial N,N,O Ligand Design

被引：8

作者：

Monkcom, Emily C. ^{[1
]}

Ghosh, Pradip ^{[1
]}

Folkertsma, Emma ^{[1
]}

Negenman, Hidde A. ^{[1
]}

Lutz, Martin ^{[2
]}

Gebbink, Robertus J. M. Klein ^{[1
]}

机构：

[1] Univ Utrecht, Organ Chem & Catalysis, Debye Inst Nanomat Sci, Fac Sci, NL-3584 CG Utrecht, Netherlands

[2] Univ Utrecht, Crystal & Struct Chem, Bijvoet Ctr Biomol Res, Fac Sci, NL-3584 CH Utrecht, Netherlands

来源：

CHIMIA | 2020年 / 74卷 / 06期

关键词：

Bioinspired metal complexes; 2-His-1-Carboxylate facial triad; N; O Ligands; Non-heme iron; TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE; ISOPENICILLIN N SYNTHASE; FUNCTIONAL MODELS; DONOR LIGANDS; ACTIVE-SITES; HETEROSCORPIONATE LIGANDS; IRON(III) COMPLEXES; ZINC(II) COMPLEXES; ENZYMES; OXIDATION;

D O I：

10.2533/chimia.2020.450

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Iron-containing metalloenzymes that contain the 2-His-1-Carboxylate facial triad at their active site are well known for their ability to activate molecular oxygen and catalyse a broad range of oxidative transformations. Many of these reactions are synthetically challenging, and developing small molecular iron-based catalysts that can achieve similar reactivity and selectivity remains a long-standing goal in homogeneous catalysis. This review focuses on the development of bioinspired facial N,N,O ligands that model the 2-His-1-Carboxylate facial triad to a greater degree of structural accuracy than many of the polydentate N-donor ligands commonly used in this field. By developing robust, well-defined N,N,O facial ligands, an increased understanding could be gained of the factors governing enzymatic reactivity and selectivity.

引用

页码：450 / 466

页数：17

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