Measurement and Correlation of Solubility of Loratadine in Different Pure Solvents and Binary Mixtures

The solubility of loratadine in pure solvents and binary mixed solvents is measured at the temperature range from 283.15 to 323.15 K using a laser technique. The results indicate that the solubility of loratadine increases with the increasing temperature in all these selected solvents: The solubility of loratadine reaches the maximum value when the mole fraction of methanol is 0.7 in the binary, solvent mixtures of methanol + acetonitrile. Also, in the system of n-pentanol + acetonitrile mixed solvent the solubility reaches the maximum value when the mole-fraction of n-pentanol is 0.6. The modified Apelblat equation and three parameters van't Hoff equation are applied to correlate the experimental solubility in pure solvents. In binary Mixed solvents, the modified Apelblat equation and Jouyban-Acree model are used to correlate the solubility data.