The zebrafish model in oncology

被引：0
作者：
不详
机构：
来源：
M S-MEDECINE SCIENCES | 2018年 / 34卷 / 04期
关键词：
DIFFERENT DEVELOPMENTAL-STAGES; NERVE SHEATH TUMORS; TRANSGENIC ZEBRAFISH; IN-VIVO; DANIO-RERIO; EMBRYONAL RHABDOMYOSARCOMA; BRACHYDANIO-RERIO; EXPOSURE ROUTES; GENETIC SCREEN; LIVER-TUMORS;
D O I：
10.1051/medsci/20183404000
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Although cell culture and mouse models will remain a cornerstone of cancer research, the unique capabilities of the zebrafish outline the potential of this model for shedding light on cancer biology in vivo. Zebrafish develops cancers spontaneously, after chemical mutagenesis or through genetic manipulations. Furthermore, zebrafish cancers are similar to human tumors at the histological and molecular levels allowing the study of tumor initiation, progression and heterogeneity. Xenotransplantation of human cancer cells in embryos or adult zebrafish presents the advantage of following cancer cell behavior in vivo. Finally, zebrafish embryos are used in molecule screens and contribute to the identification of novel anti-cancer therapeutic strategies. Here, we review different involvements of the zebrafish model in cancer research.
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页码：344 / 353
页数：10
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