Anti-ENA antibodies in patients with chronic hepatitis C virus infection

被引：27

作者：

D'Amico, E

Palazzi, C

Cacciatore, P

Canelli, A

Ursitti, G

Cosentino, L

Dogali, V

Riario-Sforza, G

Capani, F

机构：

[1] Osped Civile Spirito Santo, Dept Internal Med, Pescara, Italy

[2] Osped Civile Spirito Santo, Dept Lab Med, Pescara, Italy

[3] Villa Pini Clin, Div Rheumatol, Chieti, Italy

来源：

DIGESTIVE DISEASES AND SCIENCES | 2002年 / 47卷 / 04期

关键词：

hepatitis C virus; anti-ENA antibodies; sicca syndrome; Sjogren's syndrome;

D O I：

10.1023/A:1014731731363

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The aim of the study was to assess the prevalence of anti-extractable nuclear antigen (ENA) antibodies in patients with chronic HCV infection. We studied 69 consecutive patients with chronic hepatitis C, 59 control subjects with non-HCV liver diseases, and 22 control subjects with extrahepatic, non-immune-mediated, chronic diseases. Thirty-two (46.3%) of 69 patients with HCV infection had anti-ENA antibodies: 16 (23.1%) showed anti-SSA antibodies and 14 (20.2%) had anti-SSB antibodies. Four of the patients with HCV infection suffered from sicca syndrome and three of them had also anti ENA antibodies. The prevalence of anti-ENA antibodies was significantly higher in the anti-HCV subjects compared with both control groups. Twenty-six of 44 HCV-antibodies-positive females had anti-ENA antibodies, compared with 6 of 25 mates, showing a sex related difference. In conclusion, our results outline a specific role of HCV infection in the induction of anti-ENA antibodies. Female sex seems a predisposing condition.

引用

页码：755 / 759

页数：5

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