Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period

被引：10

作者：

Soiza-Reilly, M ^{[1
]}

Fossati, M ^{[1
]}

Ibarra, GR ^{[1
]}

Azcurra, JM ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Lab Biol Celular, RA-1602 Buenos Aires, DF, Argentina

来源：

BRAIN RESEARCH | 2004年 / 1004卷 / 1-2期

关键词：

motor plasticity; dopamine; rat striatum; critical period; D1; receptor; D2;

D O I：

10.1016/j.brainres.2004.01.050

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained rats showed a decrease of 40% in D2R binding sites (p < 0.01) and of 45% in the D2R mRNA expression which involve short (p < 0.05) and long (p < 0.01) isoforms. In contrast, D1R binding sites nor its mRNA expression levels were affected by training, indicating a differential synaptic refinement during this ontogenetically fixed period. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：217 / 221

页数：5