Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool

被引：176
作者：
Iacobazzi, Vito [1 ,2 ,3 ]
Castegna, Alessandra [1 ]
Infantino, Vittoria [1 ,4 ]
Andria, Generoso [5 ]
机构：
[1] Univ Bari, Dept Biosci Biotechnol & Pharmacol Sci, I-70125 Bari, Italy
[2] Univ Bari, Ctr Excellence Comparat Genom, I-70125 Bari, Italy
[3] CNR, Inst Biomembranes & Bioenerget, I-70126 Bari, Italy
[4] Univ Basilicata, Dept Sci, I-85100 Potenza, Italy
[5] Univ Naples Federico II, Sect Pediat, Dept Translat Med Sci, Naples, Italy
来源：
MOLECULAR GENETICS AND METABOLISM | 2013年 / 110卷 / 1-2期
关键词：
Mitochondrial DNA; Epigenetics; Methylation; Biomarker; MEDIATED CYTOSINE CONVERSION; CPG-ISLAND METHYLATION; GENOME-WIDE; RIBOSOMAL-RNA; HUMAN-CELLS; IN-VIVO; MASS-SPECTROMETRY; CANCER-CELLS; MAMMALIAN MITOCHONDRIA; S-ADENOSYLMETHIONINE;
D O I：
10.1016/j.ymgme.2013.07.012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent expansion of our knowledge on epigenetic changes strongly suggests that not only nuclear DNA (nDNA), but also mitochondrial DNA (mtDNA) may be subjected to epigenetic modifications related to disease development, environmental exposure, drug treatment and aging. Thus, mtDNA methylation is attracting increasing attention as a potential biomarker for the detection and diagnosis of diseases and the understanding of cellular behavior in particular conditions. In this paper we review the current advances in mtDNA methylation studies with particular attention to the evidences of mtDNA methylation changes in diseases and physiological conditions so far investigated. Technological advances for the analysis of epigenetic variations are promising tools to provide insights into methylation of mtDNA with similar resolution levels as those reached for nDNA. However, many aspects related to mtDNA methylation are still unclear. More studies are needed to understand whether and how changes in mtDNA methylation patterns, global and gene specific, are associated to diseases or risk factors. (C) 2013 Elsevier Inc. All rights reserved.
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收藏
页码：25 / 34
页数：10
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