Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities

被引：75
作者：
El-Borai, Mohamed A. [1 ]
Rizk, Hala F. [1 ]
Beltagy, Doha M. [2 ]
El-Deeb, Ibrahim Y. [1 ]
机构：
[1] Tanta Univ, Fac Sci, Dept Chem, Tanta 31527, Egypt
[2] Damanhour Univ, Fac Sci, Dept Chem, Damanhour, Egypt
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 66卷
关键词：
Enaminones; Microwave technology; Antioxidant; Antitumor; Antimicrobial activities; CORONARY-HEART-DISEASE; ORGANIC-SYNTHESIS; PREVENTION; EPIDEMIOLOGY; IRRADIATION; DERIVATIVES; NUTRITION; CHEMISTRY; ENAMINONE;
D O I：
10.1016/j.ejmech.2013.04.043
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The chemical behavior of 4-(dimethylaminomethylene)-1-phenyl-3-(pyridin-3-yl)-1H-pyrazol-5(4H)-one (enaminone) (2) toward some active methylene reagents has been reported to give pyrazolopyridine derivatives. All the reactions were carried out by conventional heating and microwave irradiation technique. The antioxidant activity of the prepared compounds was studied using 1,1-phenyl-2-picrylhydrazyl (DPPH) assay. Compounds (4c) and (4d) showed the highest activity. The antitumor activity against liver and breast cell lines was tested. Compounds (6), (9) and (11) showed the highest activity for liver cell line while compounds (6) and (9) showed the highest activity for breast cell line. Compounds (4a-d) were screened for their antibacterial activity against Gram-positive, Gram-negative bacteria and antifungal activity. (C) 2013 Elsevier Masson SAS. All rights reserved.
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收藏
页码：415 / 422
页数：8
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