N- vs O-alkylation in 2(1H)-quinolinone derivatives

被引：24

作者：

Guo, ZX

Cammidge, AN ^{[1
]}

McKillop, A

Horwell, DC

机构：

[1] Univ E Anglia, Sch Chem Sci, Norwich NR4 7TJ, Norfolk, England

[2] Parke Davis Neurosci Res Ctr, Cambridge CB2 2QB, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 38期

关键词：

alkylation; quinolinones; phase transfer;

D O I：

10.1016/S0040-4039(99)01422-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N- vs O-alkylation reactions of 8-benzyloxy-2(1H)-quinolinone have been investigated using both classical and phase transfer conditions. The influence of reaction solvents/conditions was found to have a dramatic effect on selectivity, with opposite trends to that observed for 2-pyridone alkylation. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：6999 / 7002

页数：4

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