No-carrier-added versus carrier-added123I-metaiodobenzylguanidine for the assessment of cardiac sympathetic nerve activity

被引:19
作者
Verberne, HJ
de Bruin, K
Habraken, JBA
Somsen, GA
Eersels, JLH
Moet, F
Booij, J
van Eck-Smit, BLF
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, NL-1100 DE Amsterdam, Netherlands
[2] Tyco Healthcare BV, Mallinckrodt Med, Petten, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Nucl Med & PET Res, NL-1100 DE Amsterdam, Netherlands
[4] Onze Lieve Vrouw Hosp, Dept Cardiol, Amsterdam, Netherlands
关键词
iodine-123; metaiodobenzylguanidine; no carrier added; myocardial; sympathetic nerve activity;
D O I
10.1007/s00259-005-0022-1
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: No-carrier-added (nca) MIBG is primarily associated with specific uptake (i.e. uptake-1 mechanism). We evaluated the hypothesis that nca MIBG will be less influenced by changes in extra-neuronal uptake (i.e. uptake-2 mechanism) compared with carrier-added (ca) MIBG. Methods: No-carrier-added MIBG was compared with ca MIBG of two different manufacturers (ca MIBG-1 and ca MIBG-2, with a specific activity of 200 Mq/mu mol and 40 MBq/mu mol MIBG respectively) in rats (n=6 per group): controls, blocking uptake-1 (desipramine) and blocking uptake-2 (phenoxybenzamine hydrochloride). Dedicated pinhole SPECT was performed 2 h after injection of the radiotracer. After SPECT, biodistribution was assessed [% injected dose per gram tissue (%ID)]. Results: No-carrier-added MIBG had the highest absolute cardiac uptake. Although a clear trend was observed, nca MIBG was not statistically significantly different from ca MIBG-1 (0.31 +/- 0.05 %ID vs 0.25 +/- 0.01 %ID,p=0.05). Blocking uptake-1 resulted in a significant decrease in absolute cardiac uptake only for nca MIBG (0.22 +/- 0.03 %ID,p=0.004). Blocking uptake-2 resulted in a significant reduction in ca MIBG-1 cardiac uptake (0.14 +/- 0.02 %ID,p=0.0001), but not in the cardiac uptake of nca MIBG or MIBG-2. SPECT showed the highest relative cardiac uptake for nca MIBG. Poor contrast between myocardium and surrounding tissue hampered assessment of relative cardiac uptake on SPECT of both ca MIBG-1 and ca MIBG-2. Conclusion: No-carrier-added MIBG yields a higher myocardial uptake than ca MIBG and is associated with a higher specific as well as a lower non-neuronal uptake. We therefore conclude that for the scintigraphic assessment of the myocardial sympathetic nervous system, nca MIBG is to be preferred over ca MIBG.
引用
收藏
页码:483 / 490
页数:8
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