Asymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with β-nitroalkenes catalyzed by chiral bifunctional thioureas

被引：28

作者：

Mei, Ren-Qiang ^{[1
,2
]}

Xu, Xiao-Ying ^{[1
]}

Peng, Lin ^{[1
]}

Wang, Fan ^{[1
,2
]}

Tian, Fang ^{[1
]}

Wang, Li-Xin ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 10039, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 08期

基金：

中国国家自然科学基金;

关键词：

CYCLIC 1,3-DICARBONYL COMPOUNDS; ENANTIOSELECTIVE CONJUGATE ADDITION; SOLID-PHASE SYNTHESIS; MICHAEL ADDITION; ALPHA; BETA-UNSATURATED KETONES; DERIVATIVES; NITRO; 4-HYDROXYPYRONE; MECHANISM; SCOPE;

D O I：

10.1039/c2ob27121d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first asymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with nitroolefins catalyzed by chiral bifunctional thioureas was reported and 2,3-dihydrofuro[3,2-c]-coumarin adducts have been obtained in moderate yields (53-75%) and good enantioselectivities (64-90% ee).

引用

页码：1286 / 1289

页数：4

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