Asymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with β-nitroalkenes catalyzed by chiral bifunctional thioureas

被引：28
|
作者：
Mei, Ren-Qiang [1 ,2 ]
Xu, Xiao-Ying [1 ]
Peng, Lin [1 ]
Wang, Fan [1 ,2 ]
Tian, Fang [1 ]
Wang, Li-Xin [1 ]
机构：
[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China
[2] Chinese Acad Sci, Grad Univ, Beijing 10039, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 08期
基金：
中国国家自然科学基金;
关键词：
CYCLIC 1,3-DICARBONYL COMPOUNDS; ENANTIOSELECTIVE CONJUGATE ADDITION; SOLID-PHASE SYNTHESIS; MICHAEL ADDITION; ALPHA; BETA-UNSATURATED KETONES; DERIVATIVES; NITRO; 4-HYDROXYPYRONE; MECHANISM; SCOPE;
D O I：
10.1039/c2ob27121d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first asymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with nitroolefins catalyzed by chiral bifunctional thioureas was reported and 2,3-dihydrofuro[3,2-c]-coumarin adducts have been obtained in moderate yields (53-75%) and good enantioselectivities (64-90% ee).
引用
收藏
页码：1286 / 1289
页数：4
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