Neonatal Herpes Encephalitis Caused by a Virologically Confirmed Acyclovir-Resistant Herpes Simplex Virus 1 Strain

被引：23

作者：

Kakiuchi, Satsuki ^{[1
,4
]}

Nonoyama, Shigeaki ^{[2
]}

Wakamatsu, Hajime ^{[2
]}

Kogawa, Kazuhiro ^{[2
]}

Wang, Lixin ^{[1
]}

Kinoshita-Yamaguchi, Hitomi ^{[1
]}

Takayama-Ito, Mutsuyo ^{[1
]}

Lim, Chang-Kweng ^{[1
]}

Inoue, Naoki ^{[1
]}

Mizuguchi, Masashi ^{[3
]}

Igarashi, Takashi ^{[4
]}

Saijo, Masayuki ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Virol 1, Tokyo, Japan

[2] Natl Def Med Coll, Dept Pediat, Saitama, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Dev Med Sci, Tokyo, Japan

[4] Univ Tokyo, Grad Sch Med, Dept Pediat, Tokyo, Japan

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2013年 / 51卷 / 01期

基金：

日本学术振兴会;

关键词：

POLYMERASE-CHAIN-REACTION; THYMIDINE KINASE; TYPE-1; INFECTIONS; MANAGEMENT; DISEASE;

D O I：

10.1128/JCM.02247-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A neonate with herpes simplex virus 1 encephalitis was treated with intravenous acyclovir. During the course of therapy, the infection became intractable to the treatment and a mutation in the viral thymidine kinase gene (nucleotide G375T, amino acid Q125H) developed. This mutation was demonstrated in vitro to confer acyclovir resistance.

引用

页码：356 / 359

页数：4

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