A NOVEL P53-DEPENDENT APOPTOSIS FUNCTION OF TARSH IN TUMOR DEVELOPMENT

被引：0
作者：
Wakoh, Takeshi [1 ]
Sugimoto, Masataka [1 ]
Terauchi, Kunihiko [2 ]
Shimada, Jun-ichi [2 ]
Maruyama, Mitsuo [1 ]
机构：
[1] Natl Inst Longev Sci, Dept Mech Aging, Natl Ctr Geriatr & Gerontol, Morioka, Obu 4748522, Japan
[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Cardiovasc & Thorac Surg, Kyoto 6028566, Japan
来源：
NAGOYA JOURNAL OF MEDICAL SCIENCE | 2009年 / 71卷 / 3-4期
关键词：
Cell cycle; Apoptosis; Tumor suppression; TARSH; p53;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A target of NESH-SH3/Abi3bp (TARSH) was originally identified as an SH3 domain-binding molecule of the NESH-SH3/Abi3 protein that is involved in Rac-dependent actin polymerization. In recent studies, TARSH gene expression was dramatically induced in mouse embryonic fibroblasts (MEFs) replicative senescence and suppressed in human lung carcinoma specimens and thyroid carcinomas. However, the molecular mechanism underlying the regulation of TARSH in tumorigenesis remains unclear. Here, we address a p53-dependent apoptosis function of the mouse TARSH gene using RNAi-mediated suppression of endogenous TARSH expression. Our results will be useful in the discovery of a novel therapeutic target in lung carcinoma.
引用
收藏
页码：109 / 114
页数：6
相关论文
共 15 条
  • [1] Cell death by mitotic catastrophe: a molecular definition
    Castedo, M
    Perfettini, JL
    Roumie, T
    Andreau, K
    Medema, R
    Kroemer, G
    [J]. ONCOGENE, 2004, 23 (16) : 2825 - 2837
  • [2] A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression
    Cerutti, JM
    Delcelo, R
    Amadei, MJ
    Nakabashi, C
    Maciel, RMB
    Peterson, B
    Shoemaker, J
    Riggins, GJ
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (08) : 1234 - 1242
  • [3] Apoptosis and the cell cycle: the p53 connection
    Choisy-Rossi, C
    Yonish-Rouach, E
    [J]. CELL DEATH AND DIFFERENTIATION, 1998, 5 (02) : 129 - 131
  • [4] Ichigotani Y, 2002, CANCER RES, V62, P2215
  • [5] The P53 pathway: what questions remain to be explored?
    Levine, A. J.
    Hu, W.
    Feng, Z.
    [J]. CELL DEATH AND DIFFERENTIATION, 2006, 13 (06) : 1027 - 1036
  • [6] p53, the cellular gatekeeper for growth and division
    Levine, AJ
    [J]. CELL, 1997, 88 (03) : 323 - 331
  • [7] Intrinsic tumour suppression
    Lowe, SW
    Cepero, E
    Evan, G
    [J]. NATURE, 2004, 432 (7015) : 307 - 315
  • [8] Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53
    Maehara, K
    Yamakoshi, K
    Ohtani, N
    Kubo, Y
    Takahashi, A
    Arase, S
    Jones, N
    Hara, E
    [J]. JOURNAL OF CELL BIOLOGY, 2005, 168 (04) : 553 - 560
  • [9] Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3
    Matsuda, S
    Iriyama, C
    Yokozaki, S
    Ichigotani, Y
    Shirafuji, N
    Yamaki, K
    Hayakawa, T
    Hamaguchi, M
    [J]. JOURNAL OF HUMAN GENETICS, 2001, 46 (08) : 483 - 486
  • [10] IDENTIFICATION AND INHIBITION OF THE ICE/CED-3 PROTEASE NECESSARY FOR MAMMALIAN APOPTOSIS
    NICHOLSON, DW
    ALI, A
    THORNBERRY, NA
    VAILLANCOURT, JP
    DING, CK
    GALLANT, M
    GAREAU, Y
    GRIFFIN, PR
    LABELLE, M
    LAZEBNIK, YA
    MUNDAY, NA
    RAJU, SM
    SMULSON, ME
    YAMIN, TT
    YU, VL
    MILLER, DK
    [J]. NATURE, 1995, 376 (6535) : 37 - 43
12