Detection of glutathione based on MnO2 nanosheet-gated mesoporous silica nanoparticles and target induced release of glucose measured with a portable glucose meter

被引：41

作者：

Tan, Qingqing ^{[1
]}

Zhang, Ruirui ^{[2
]}

Kong, Rongmei ^{[1
]}

Kong, Weisu ^{[1
]}

Zhao, Wenzhi ^{[1
]}

Qu, Fengli ^{[1
]}

机构：

[1] Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China

[2] Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing Key Lab Ionic Liquids Clean Proc, Beijing 100190, Peoples R China

来源：

MICROCHIMICA ACTA | 2018年 / 185卷 / 01期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

MnO2; nanosheets; Mesoporous silica; Personal glucose meter; Glutathione; Portable detection; Target induced release; FLUORESCENT-PROBE; LIVING CELLS; CARBON DOTS; ON ASSAY; PLATFORM; THIOLS; SWITCH;

D O I：

10.1007/s00604-017-2603-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The authors describe a novel method for the determination of glutathione (GSH). Detection is based on target induced release of glucose from MnO2 nanosheet-gated aminated mesoporous silica nanoparticles (MSNs). In detail, glucose is loaded into the pores of MSNs. Negatively charged MnO2 nanosheets are assembled on the MSNs through electrostatic interactions. The nanosheets are reduced by GSH, and this results in the release of glucose which is quantified by using a commercial electrochemical glucose meter. GSH can be quantified by this method in the 100 nM to 10 mu M concentration range, with a 34 nM limit of detection.

引用

页数：7

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