The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer's disease

被引：16

作者：

Makitalo, Signar ^{[1
]}

Mellgren, Asa ^{[2
,3
]}

Borgh, Ellen ^{[4
]}

Kilander, Lena ^{[5
]}

Skillback, Tobias ^{[6
]}

Zetterberg, Henrik ^{[6
,7
]}

Gisslen, Magnus ^{[3
]}

机构：

[1] Gavle Cent Hosp, Dept Infect Dis, S-80187 Gavle, Sweden

[2] South Alvsborg Hosp, Clin Infect Dis, Boras, Sweden

[3] Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Infect Dis, Gothenburg, Sweden

[4] Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Resp Med, Gothenburg, Sweden

[5] Uppsala Univ, Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden

[6] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Clin Neurochem Lab, Molndal, Sweden

[7] UCL Inst Neurol, London, England

来源：

AIDS RESEARCH AND THERAPY | 2015年 / 12卷

基金：

瑞典研究理事会;

关键词：

Alzheimer's disease; HIV; CSF biomarkers; NEUROFILAMENT PROTEIN NFL; CENTRAL-NERVOUS-SYSTEM; ANTIRETROVIRAL THERAPY; LIFE EXPECTANCY; TAU-PROTEIN; DEMENTIA; CSF; INDIVIDUALS; DIAGNOSIS; MARKER;

D O I：

10.1186/s12981-015-0063-x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

It is a challenge to differentiate between HIV-associated neurocognitive disorders (HAND) and other types of neurocognitive disease in the ageing HIV-infected population. Here we describe a 63 year old HIV-infected woman who had a history, neuropsychological test result, and PET examination consistent with characteristic Alzheimer's disease (AD). The cerebrospinal fluid (CSF) biomarker profile was analogous to the profile typically found in AD in HIV-negative patients with increased t-tau and p-tau, a decreased level of A beta 42 and normal levels of CSF neurofilament light protein and sAPP alpha and sAPP beta, distinctly different from findings in HIV-associated dementia (HAD). Assessment of CSF biomarkers may be a valuable tool for clinicians to distinguish between HAD and AD.

引用

页数：5

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