Cancer incidence in a chlorochemical plant in Isere, France: An occupational cohort study, 1979-2002

被引：11

作者：

Bonneterre, Vincent ^{[2
]}

Mathern, Gerard ^{[3
]}

Pelen, Odile ^{[3
]}

Balthazard, Anne-Laure

Delafosse, Patricia ^{[1
]}

Mitton, Nicolas ^{[1
]}

Colonna, Marc ^{[1
]}

机构：

[1] CHU Grenoble, Registre Canc Isere, F-38043 Grenoble 9, France

[2] UJF Grenoble 1, CNRS, TIMC IMAG UMR 5525, EPSP Team, Grenoble, France

[3] Serv Sante Au Travail, Le Pont De Claix, France

来源：

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE | 2012年 / 55卷 / 09期

关键词：

occupational exposure (MeSH); epidemiology (MeSH); cohort studies (MeSH); cancer (MeSH?=?neoplasm); chemical industry (MeSH); occupational health (MeSH); occupational diseases (MeSH); PHENOXY HERBICIDES; EXPOSED WORKERS; MORTALITY; DIOXINS; INDUSTRY; PENTACHLOROPHENOL; CHLOROPHENOLS; CONTAMINANTS; FORMULATIONS; ASBESTOS;

D O I：

10.1002/ajim.22069

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background A major French chlorine chemical plant (chlor-alkali process with diaphragm cell and manufacturing of organochlorine chemicals) has used or produced known or suspected carcinogenic compounds. Methods A cohort study, based on the plant occupational health service and the regional cancer registry, analyzed the standardized incidence ratios of malignant tumors for the period 1979-2002. Individual exposures were estimated from workers' occupational histories in a dual division of jobs into 9 sectors and 115 workshops with known exposures. Results Men (2,742) were followed, corresponding to 52,794 person-years. Primary tumors (304) were observed for 290 expected cases, a non-significant 5% excess. A significant excess was found of pleural mesothelioma and bladder cancer in employees hired before 1964. Conclusion Excesses of mesothelioma and bladder cancer were found, whereas there was no excess of hematopoietic cancers despite high benzene and dioxin exposures. Surprisingly, mesothelioma cases did not include workers who were the most exposed to asbestos. Am. J. Ind. Med. 55:756767, 2012. (c) 2012 Wiley Periodicals, Inc.

引用

页码：756 / 767

页数：12

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