Dengue Virus and Zika Virus Serological Cross-reactivity and Their Impact on Pathogenesis in Mice

被引：33

作者：

Watanabe, Satoru ^{[1
]}

Tan, Nicole Wei Wen ^{[1
]}

Chan, Kitti Wing Ki ^{[1
]}

Vasudevan, Subhash G. ^{[1
]}

机构：

[1] Duke NUS Med Sch, Program Emerging Infect Dis, 8 Coll Rd, Singapore 169857, Singapore

来源：

JOURNAL OF INFECTIOUS DISEASES | 2019年 / 219卷 / 02期

基金：

英国医学研究理事会;

关键词：

Dengue virus; Zika virus; antibody-dependent enhancement; serological cross-reactivity; vaccine design; ANTIBODY-DEPENDENT ENHANCEMENT; CD8(+) T-CELLS; INFECTION; PROTECTION; MODELS;

D O I：

10.1093/infdis/jiy482

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Preexisting immunity to Zika virus (ZIKV) or dengue virus (DENV) may alter the course of their infection, and here we use robust mouse models to examine pathological outcomes following passive immunization, sequential cross-infection, or vaccination with inactivated virus. DENV infection was enhanced (through antibody-dependent enhancement [ADE]) or was suppressed by both DENV and ZIKV immunity. Notably, inactivated ZIKV vaccination enhanced dengue disease severity, although it was highly protective against ZIKV infection. On the other hand, ADE was not observed upon ZIKV infection in mice that were passively immunized or preinfected with DENV. Surprisingly, however, we found that vaccination with inactivated DENV enhanced ZIKV infection, mainly in the mesenteric lymph node, indicating the potential for DENV immunity to cause ADE in vivo. Collectively, our data call for greater attention to detail in the design of ZIKV or DENV vaccines.

引用

页码：223 / 233

页数：11

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