Carbocyclic analogues of D-ribose-5-phosphate: Synthesis and behavior with 5-phosphoribosyl alpha-1-pyrophosphate synthetases

被引：15

作者：

Parry, RJ ^{[1
]}

Burns, MR ^{[1
]}

Skae, PN ^{[1
]}

Hoyt, JC ^{[1
]}

Pal, B ^{[1
]}

机构：

[1] RICE UNIV, DEPT CHEM, HOUSTON, TX 77251 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 07期

关键词：

D O I：

10.1016/0968-0896(96)00090-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of cyclopentyl and cyclopentenyl analogues of the cr-anomer of D-ribose-5-phosphate from D-ribonolactone and D-ribose is described. These analogues, which have the same absolute configuration as D-ribose-5-phosphate, were incubated with PRPP synthetases in an attempt to prepare the corresponding carbocyclic PRPP analogues. The carbocyclic ribose-5-phosphate analogues were found to be inhibitors, rather than substrates, for 5-phosphoribosyl alpha-1-pyrophosphate synthetases of both bacterial and human origin. The inhibitory behavior of the analogues is described. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1077 / 1088

页数：12

共 53 条

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[2]

[Anonymous], 1983, Metabolism of Nucleotides, Nucleosides and Nucleobases in Microorganisms

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