Carbon quantum dots from roasted Atlantic salmon (Salmo salar L.): Formation, biodistribution and cytotoxicity

被引：70
作者：
Song, Yukun [1 ]
Wu, Yanyang [1 ]
Wang, Haitao [1 ]
Liu, Shan [1 ]
Song, Liang [1 ]
Li, Shen [2 ]
Tan, Mingqian [1 ]
机构：
[1] Dalian Polytech Univ, Sch Food Sci & Technol, Natl Engn Res Ctr Seafood, Qinggongyuan 1, Dalian 116034, Peoples R China
[2] Dalian Med Univ, Dalian Municipal Cent Hosp, Dept Endocrinol, Dalian 116033, Peoples R China
来源：
FOOD CHEMISTRY | 2019年 / 293卷
基金：
中国国家自然科学基金;
关键词：
Carbon quantum dots; Salmo salar L; Biodistribution; Flow cytometric; Energy metabolism; PHOTOLUMINESCENCE PROPERTIES; STEM-CELLS; NANOPARTICLES; AUTOPHAGY; LC3;
D O I：
10.1016/j.foodchem.2019.05.017
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The endogenous carbon quantum dots (CQDs) produced during food processing have potential uncertainty to human health. The objective of this study was to investigate the formation, biodistribution and cytotoxicity of CQDs in roasted Atlantic salmon (Salmo salar Linnaeus). The X-ray photoelectron spectroscopy (XPS) analysis showed that the CQDs were mainly composed of carbon, oxygen and nitrogen. The morphology, functional groups and optical properties were highly dependent on the roasting time. In vivo experiments in mice demonstrated that the CQDs distributed in the digestive tract, kidney, liver, and even brain, which indicated that they could cross the blood-brain barrier. The cell imaging results indicated that the CQDs could readily gain access to the normal rat kidney (NRK) cells, and caused autophagosome formation. The proportion of live cells decreased to 34.62% at 6 mg mL(-1) of CQDs, and the energy generation route was changed from aerobic to glycolytic metabolism.
引用
收藏
页码：387 / 395
页数：9
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