A Study Assessing the Association of Glycated Hemoglobin A1C (HbA1C) Associated Variants with HbA1C, Chronic Kidney Disease and Diabetic Retinopathy in Populations of Asian Ancestry

被引：6

作者：

Chen, Peng ^{[1
]}

Ong, Rick Twee-Hee ^{[1
]}

Tay, Wan-Ting ^{[2
]}

Sim, Xueling ^{[1
]}

Ali, Mohammad ^{[4
]}

Xu, Haiyan ^{[1
]}

Suo, Chen ^{[1
]}

Liu, Jianjun ^{[5
]}

Chia, Kee-Seng ^{[1
]}

Vithana, Eranga ^{[2
,6
]}

Young, Terri L. ^{[11
]}

Aung, Tin ^{[2
,6
]}

Lim, Wei-Yen ^{[1
]}

Khor, Chiea-Chuen ^{[1
,3
,5
,6
]}

Cheng, Ching-Yu ^{[1
,2
,6
,10
]}

Wong, Tien-Yin ^{[2
,6
,7
,8
]}

Teo, Yik-Ying ^{[1
,4
,5
,9
,13
]}

Tai, E-Shyong ^{[1
,8
,12
]}

机构：

[1] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore

[2] Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore

[3] Natl Univ Singapore, Dept Paediat, Singapore 117548, Singapore

[4] Natl Univ Singapore, Inst Life Sci, Singapore 117548, Singapore

[5] Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore

[6] Natl Univ Singapore, Dept Ophthalmol, Singapore 117548, Singapore

[7] Univ Melbourne, Ctr Eye Res Australia, Melbourne, Vic, Australia

[8] Natl Univ Singapore, Dept Med, Singapore 117548, Singapore

[9] Natl Univ Singapore, Dept Stat & Appl Probabil, Singapore 117548, Singapore

[10] Duke NUS Grad Med Sch, Off Clin Sci, Ctr Quantitat Med, Singapore, Singapore

[11] Duke Univ, Ctr Human Genet, Med Ctr, Durham, NC USA

[12] Duke NUS Grad Med Sch, Singapore, Singapore

[13] Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore 117548, Singapore

来源：

PLOS ONE | 2013年 / 8卷 / 11期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; ETHNIC-DIFFERENCES; RISK-FACTORS; SUSCEPTIBILITY LOCI; NATIONAL-HEALTH; GLUCOSE; METAANALYSIS; PREVALENCE; COMPONENTS; EFFICIENCY;

D O I：

10.1371/journal.pone.0079767

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Glycated hemoglobin A(1C) (HbA(1C)) level is used as a diagnostic marker for diabetes mellitus and a predictor of diabetes associated complications. Genome-wide association studies have identified genetic variants associated with HbA(1C) level. Most of these studies have been conducted in populations of European ancestry. Here we report the findings from a meta-analysis of genome-wide association studies of HbA(1C) levels in 6,682 non-diabetic subjects of Chinese, Malay and South Asian ancestries. We also sought to examine the associations between HbA(1C) associated SNPs and microvascular complications associated with diabetes mellitus, namely chronic kidney disease and retinopathy. A cluster of 6 SNPs on chromosome 17 showed an association with HbA(1C) which achieved genome-wide significance in the Malays but not in Chinese and Asian Indians. No other variants achieved genome-wide significance in the individual studies or in the meta-analysis. When we investigated the reproducibility of the findings that emerged from the European studies, six loci out of fifteen were found to be associated with HbA(1C) with effect sizes similar to those reported in the populations of European ancestry and P-value <= 0.05. No convincing associations with chronic kidney disease and retinopathy were identified in this study.

引用

页数：11

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