Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense

被引：305

作者：

Bosch, Marta ^{[1
,2
]}

Sanchez-Alvarez, Miguel ^{[3
]}

Fajardo, Alba ^{[1
]}

Kapetanovic, Ronan ^{[4
,5
,6
]}

Steiner, Bernhard ^{[4
]}

Dutra, Filipe ^{[7
]}

Moreira, Luciana ^{[7
]}

Antonio Lopez, Juan ^{[8
,9
]}

Campo, Rocio ^{[8
]}

Mari, Montserrat ^{[10
,11
]}

Morales-Paytuvi, Frederic ^{[1
]}

Tort, Olivia ^{[1
]}

Gubern, Albert ^{[1
]}

Templin, Rachel M. ^{[4
,12
]}

Curson, James E. B. ^{[4
,5
,6
]}

Martel, Nick ^{[4
]}

Catala, Cristina ^{[13
]}

Lozano, Francisco ^{[13
]}

Tebar, Francesc ^{[1
,2
]}

Enrich, Carlos ^{[1
,2
]}

Vazquez, Jesus ^{[8
,9
]}

Del Pozo, Miguel A. ^{[3
]}

Sweet, Matthew J. ^{[4
,5
,6
]}

Bozza, Patricia T. ^{[7
]}

Gross, Steven P. ^{[14
]}

Parton, Robert G. ^{[4
,12
]}

Pol, Albert ^{[1
,2
,15
]}

机构：

[1] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Cell Compartments & Signaling Grp, Barcelona 08036, Spain

[2] Univ Barcelona, Dept Biomed Sci, Fac Med, Barcelona 08036, Spain

[3] Ctr Nacl Invest Cardiovasc CNIC, Cell & Dev Biol Area, Mechanoadaptat & Caveolae Biol Lab, Madrid 28029, Spain

[4] Univ Queensland, Inst Mol Biosci IMB, Brisbane, Qld 4072, Australia

[5] Univ Queensland, IMB Ctr Inflammat & Dis Res, Brisbane, Qld 4072, Australia

[6] Univ Queensland, Australian Infect Dis Res Ctr, Brisbane, Qld 4072, Australia

[7] Fiocruz MS, Inst Oswaldo Cruz, Lab Imunofarmacol, BR-21040900 Rio De Janeiro, RJ, Brazil

[8] Inst Salud Carlos III, CNIC, Vasc Pathophysiol Area, Cardiovasc Prote Lab, Madrid 28029, Spain

[9] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid 28029, Spain

[10] CSIC, Inst Invest Biomed Barcelona IIBB, Dept Cell Death & Proliferat, Barcelona, Spain

[11] IDIBAPS, Hepatocellular Signaling & Canc Team, Barcelona 08036, Spain

[12] Univ Queensland, Ctr Microscopy & Microanal, Brisbane, Qld 4072, Australia

[13] IDIBAPS, Immunoreceptors Innate & Adapt Syst Team, Barcelona 08036, Spain

[14] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA

[15] Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona 08010, Spain

来源：

SCIENCE | 2020年 / 370卷 / 6514期

基金：

澳大利亚研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会; 瑞士国家科学基金会;

关键词：

RAT-LIVER; PROTEIN; IMAGE; IDENTIFICATION; VISUALIZATION; BIOGENESIS; MECHANISM; PEPTIDE;

D O I：

10.1126/science.aay8085

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD- bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection.

引用

页码：309 / +

页数：41

共 48 条

[1] A novel role for lipid droplets in the organismal antibacterial response [J].