Efficacy and safety of rufinamide in pediatric epilepsy

被引：18

作者：

Hsieh, David T. ^{[2
]}

Thiele, Elizabeth A. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Pediat Epilepsy Program, Dept Neurol, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

来源：

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS | 2013年 / 6卷 / 03期

关键词：

anticonvulsants; epilepsy; Lennox-Gastaut syndrome; rufinamide; LENNOX-GASTAUT SYNDROME; ADD-ON RUFINAMIDE; REFRACTORY EPILEPSY; DOUBLE-BLIND; LONG-TERM; CHILDREN; TOLERABILITY; SEIZURES; ADULTS; TRIAL;

D O I：

10.1177/1756285613481083

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Rufinamide is a novel anticonvulsant medication approved by the US Food and Drug Administration (FDA) in 2008 for the treatment of seizures associated with Lennox-Gastaut syndrome in patients 4 years of age and older, based upon clinical trials demonstrating clinical efficacy and tolerability. Rufinamide is especially effective for tonic-atonic seizures in Lennox-Gastaut syndrome, but is subsequently proving to be safe and effective in clinical practice for a broad patient population with refractory epilepsy. Although further research and clinical experience is needed, rufinamide holds the promise to positively impact the care of children with epilepsy. In this review, we review the use of rufinamide in pediatric epilepsy, with a focus on efficacy and safety.

引用

页码：189 / 198

页数：10

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