Palladium-Catalyzed Difluoroalkylation of Isocyanides: Access to Difluoroalkylated Phenanthridine Derivatives

被引：104

作者：

Gu, Ji-Wei ^{[1
]}

Zhang, Xingang ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Organofluorine Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 21期

基金：

中国国家自然科学基金;

关键词：

ARYL BORONIC ACIDS; ALPHA-ARYLATION; RADICAL TRIFLUOROMETHYLATION; FLUOROALKYLATION; PHOSPHONATES; ALKENES; ALPHA; ALPHA-DIFLUOROKETONES; DIFLUOROMETHYLATION; HETEROCYCLES; INHIBITORS;

D O I：

10.1021/acs.orglett.5b02739

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and general method for the synthesis of difluoroalkylated phenanthridine derivatives through palladium-catalyzed reaction of difluoroalkyl bromides with isocyanides is described. The reaction can also be extended to perfluoroalkyl iodides. Mechanistic studies reveal that a difluoroalkyl radical via a single-electron-transfer pathway is involved in the reaction.

引用

页码：5384 / 5387

页数：4

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