Palladium-Catalyzed Difluoroalkylation of Isocyanides: Access to Difluoroalkylated Phenanthridine Derivatives

被引：104
作者：
Gu, Ji-Wei [1 ]
Zhang, Xingang [1 ]
机构：
[1] Chinese Acad Sci, Key Lab Organofluorine Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 21期
基金：
中国国家自然科学基金;
关键词：
ARYL BORONIC ACIDS; ALPHA-ARYLATION; RADICAL TRIFLUOROMETHYLATION; FLUOROALKYLATION; PHOSPHONATES; ALKENES; ALPHA; ALPHA-DIFLUOROKETONES; DIFLUOROMETHYLATION; HETEROCYCLES; INHIBITORS;
D O I：
10.1021/acs.orglett.5b02739
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and general method for the synthesis of difluoroalkylated phenanthridine derivatives through palladium-catalyzed reaction of difluoroalkyl bromides with isocyanides is described. The reaction can also be extended to perfluoroalkyl iodides. Mechanistic studies reveal that a difluoroalkyl radical via a single-electron-transfer pathway is involved in the reaction.
引用
收藏
页码：5384 / 5387
页数：4
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