Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors

被引：55

作者：

Ady, Visou ^{[1
]}

Perroy, Julie ^{[2
,3
,4
,5
]}

Tricoire, Ludovic ^{[6
]}

Piochon, Claire ^{[6
]}

Dadak, Selma ^{[2
,3
,4
,5
]}

Chen, Xiaoru ^{[6
]}

Dusart, Isabelle ^{[6
]}

Fagni, Laurent ^{[2
,3
,4
,5
]}

Lambolez, Bertrand ^{[6
]}

Levenes, Carole ^{[1
,6
]}

机构：

[1] Univ Paris 05, Neurophys & Physiol Lab, CNRS, UMR 8119, Paris, France

[2] CNRS, UMR 5203, Inst Genom Fonct, Montpellier, France

[3] INSERM, U661, Montpellier, France

[4] Univ Montpellier I, Montpellier, France

[5] Univ Montpellier 2, Montpellier, France

[6] Univ Paris 06, CNRS, UMR 7102, Lab Neurobiol Proc Adaptifs, Paris, France

来源：

EMBO REPORTS | 2014年 / 15卷 / 01期

关键词：

GluD2; GluRdelta2; GPCR; ionotropic glutamate receptors; mGlu1; synaptic transmission; CEREBELLAR PURKINJE NEURONS; LONG-TERM DEPRESSION; SYNAPTIC-TRANSMISSION; MOTOR COORDINATION; CHANNEL PROPERTIES; CELL SYNAPSES; MUTANT MICE; POTENTIAL; D-SERINE; EXPRESSION;

D O I：

10.1002/embr.201337371

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand-gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long-standing question. Here, we show that GluD2 gating is triggered by type 1 metabotropic glutamate receptors, both in a heterologous expression system and in Purkinje cells. Thus, GluD2 is not only an adhesion molecule at synapses but also works as a channel. This gating mechanism reveals new properties of glutamate receptors that emerge from their interaction and opens unexpected perspectives regarding synaptic transmission and plasticity.

引用

页码：103 / 109

页数：7

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