Ruthenium-Catalyzed Transfer Hydrogenation of Nitriles: Reduction and Subsequent N-Monoalkylation to Secondary Amines

被引：42
作者：
Werkmeister, Svenja [1 ]
Bornschein, Christoph [1 ]
Junge, Kathrin [1 ]
Beller, Matthias [1 ]
机构：
[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 18期
关键词：
Amines; Nitriles; Alkylation; Ruthenium; Transfer hydrogenation; ASYMMETRIC HYDROGENATION; TRANSITION-METAL; ENANTIOSELECTIVE HYDROGENATION; CARBONYL-COMPOUNDS; TERTIARY-AMINES; AMINATION; ALKYLATION; ACID; EFFICIENT; ALDEHYDES;
D O I：
10.1002/ejoc.201300151
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The selective synthesis of amines continues to be of importance because of their application in the bulk and fine chemical industries. Herein, domino ruthenium-catalyzed transfer hydrogenation of nitriles with subsequent N-monoalkylation by using alcohols is described. With this novel approach, various nitriles were reductively N-monoalkylated in excellent yields.
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收藏
页码：3671 / 3674
页数：4
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