Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers

被引：55

作者：

Kramer, Paul F. ^{[1
]}

-Weil, Samuel G. Brill ^{[1
]}

Cummins, Alex C. ^{[2
]}

Zhang, Renshu ^{[1
]}

Camacho-Hernandez, Gisela A. ^{[3
]}

Newman, Amy H. ^{[3
]}

Eldridge, Mark A. G. ^{[2
]}

Averbeck, Bruno B. ^{[2
]}

Khaliq, Zayd M. ^{[1
]}

机构：

[1] Natl Inst Neurol Disorders & Stroke Intramural Res, NIH, Cellular Neurophysiol Sect, Bethesda, MD 20892 USA

[2] Natl Inst Mental Hlth Intramural Res Program, NIH, Lab Neuropsychol, Bethesda, MD 20892 USA

[3] Natl Inst Drug Abuse Intramural Res Program, NIH, Med Chem Sect, MD21224, Baltimore, MD USA

来源：

NEURON | 2022年 / 110卷 / 18期

关键词：

NICOTINIC ACETYLCHOLINE-RECEPTORS; TONICALLY ACTIVE NEURONS; ALPHA-CONOTOXIN-MII; SUBSTANTIA-NIGRA; RELEASE; NEUROTRANSMISSION; INNERVATION; ENHANCEMENT; MODULATION; ACTIVATION;

D O I：

10.1016/j.neuron.2022.07.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transmission from striatal cholinergic interneurons (CINs) controls dopamine release through nicotinic acetylcholine receptors (nAChRs) on dopaminergic axons. Anatomical studies suggest that cholinergic ter-minals signal predominantly through non-synaptic volume transmission. However, the influence of cholin-ergic transmission on electrical signaling in axons remains unclear. We examined axo-axonal transmission from CINs onto dopaminergic axons using perforated-patch recordings, which revealed rapid spontaneous EPSPs with properties characteristic of fast synapses. Pharmacology showed that axonal EPSPs (axEPSPs) were mediated primarily by high-affinity a6-containing receptors. Remarkably, axEPSPs triggered sponta-neous action potentials, suggesting that these axons perform integration to convert synaptic input into spiking, a function associated with somatodendritic compartments. We investigated the cross-species val-idity of cholinergic axo-axonal transmission by recording dopaminergic axons in macaque putamen and found similar axEPSPs. Thus, we reveal that synaptic-like neurotransmission underlies cholinergic signaling onto dopaminergic axons, supporting the idea that striatal dopamine release can occur independently of somatic firing to provide distinct signaling.

引用

页码：2949 / +

页数：17

共 75 条

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