The natural product withacnistin inhibits growth factor and cytokine-stimulated STAT3 and STAT5 tyrosine phosphorylation and induces apoptosis in human cancer cells in a STAT3-dependent manner.

被引:0
|
作者
Blaskovich, Michelle [1 ]
Sebti, Said [1 ]
机构
[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3653
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours
    X Zhang
    M A Blaskovich
    K D Forinash
    S M Sebti
    British Journal of Cancer, 2014, 111 : 894 - 902
  • [2] Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours
    Zhang, X.
    Blaskovich, M. A.
    Forinash, K. D.
    Sebti, S. M.
    BRITISH JOURNAL OF CANCER, 2014, 111 (05) : 894 - 902
  • [3] Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets
    Miyakawa, Y
    Oda, A
    Druker, BJ
    Miyazaki, H
    Handa, M
    Ohashi, H
    Ikeda, Y
    BLOOD, 1996, 87 (02) : 439 - 446
  • [4] Withacnistin blocks binding of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumors in vivo
    Zhang, Xiaolei
    Blaskovich, Michelle A.
    Forinash, Kara D.
    Sebti, Said M.
    CANCER RESEARCH, 2014, 74 (19)
  • [5] THROMBOPOIETIN (TPO) INDUCES TYROSINE PHOSPHORYLATION AND ACTIVATION OF STAT5 AND STAT3
    BACON, CM
    TORTOLANI, PJ
    SHIMOSAKA, A
    REES, RC
    LONGO, DL
    OSHEA, JJ
    FEBS LETTERS, 1995, 370 (1-2) : 63 - 68
  • [6] Thrombopoietin (TPO) induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets
    Miyakawa, Y
    Oda, A
    Druker, BJ
    Handa, M
    Miyazaki, H
    Ohashi, H
    Ikeda, Y
    BLOOD, 1995, 86 (10) : 2788 - 2788
  • [7] Hyperosmotic stress sustains cytokine-stimulated phosphorylation of STAT3, but slows its nuclear trafficking and impairs STAT3-dependent transcription
    Ng, Ivan H. W.
    Jans, David A.
    Bogoyevitch, Marie A.
    CELLULAR SIGNALLING, 2014, 26 (04) : 815 - 824
  • [8] Atiprimod blocks STAT3 and STAT5 phosphorylation, inhibits proliferation, and induces apoptosis in acute myeloid leukemia (AML) but not normal cells.
    Faderl, S
    Ferrajoli, A
    Harris, D
    Van, Q
    Kantarjian, HM
    Estrov, Z
    BLOOD, 2005, 106 (11) : 692A - 692A
  • [9] RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells
    Lee, SO
    Lou, W
    Qureshi, KM
    Mehraein-Ghomi, F
    Trump, DL
    Gao, AC
    PROSTATE, 2004, 60 (04): : 303 - 309
  • [10] Deficiency of Erbin induces resistance of cervical cancer cells to anoikis in a STAT3-dependent manner
    Y Hu
    H Chen
    C Duan
    D Liu
    L Qian
    Z Yang
    L Guo
    L Song
    M Yu
    M Hu
    M Shi
    N Guo
    Oncogenesis, 2013, 2 : e52 - e52