Asymmetric intramolecular crossed-benzoin reactions by N-heterocyclic carbene catalysis

被引：248
|
作者：
Enders, D [1 ]
Niemeier, O [1 ]
Balensiefer, T [1 ]
机构：
[1] RWTH Aachen Univ, Inst Organ Chem, D-52074 Aachen, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 09期
关键词：
asymmetric synthesis; benzoin reaction; heterocycles; homogeneous catalysis; N-heterocyclic carbenes;
D O I：
10.1002/anie.200503885
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Getting cross: Excellent asymmetric inductions and very good yields are achieved in the generation of a quaternary stereocenter in α-hydroxy-substituted tetralones by using chiral N-heterocyclic carbene catalysts in an enantioselective intramolecular crossed-benzoin reaction. The synthesis of the corresponding α-hydroxyindanones with good ee values is also possible by this route. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1463 / 1467
页数：5
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