Asymmetric intramolecular crossed-benzoin reactions by N-heterocyclic carbene catalysis

被引：248

作者：

Enders, D ^{[1
]}

Niemeier, O ^{[1
]}

Balensiefer, T ^{[1
]}

机构：

[1] RWTH Aachen Univ, Inst Organ Chem, D-52074 Aachen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 09期

关键词：

asymmetric synthesis; benzoin reaction; heterocycles; homogeneous catalysis; N-heterocyclic carbenes;

D O I：

10.1002/anie.200503885

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Getting cross: Excellent asymmetric inductions and very good yields are achieved in the generation of a quaternary stereocenter in α-hydroxy-substituted tetralones by using chiral N-heterocyclic carbene catalysts in an enantioselective intramolecular crossed-benzoin reaction. The synthesis of the corresponding α-hydroxyindanones with good ee values is also possible by this route. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1463 / 1467

页数：5

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