Wortmannin enhances CPP32-like activity during neuronal differentiation of P19 embryonal carcinoma cells induced by retinoic acid

被引：12
作者：
Mukasa, T
Khoroku, Y
Tsukahara, T
Momoi, MY
Kimura, I
Momoi, T
机构：
[1] NATL INST NEUROSCI,NCNP,DIV DEV & DIFFERENTIAT,KODAIRA,TOKYO 187,JAPAN
[2] WASEDA UNIV,FAC HUMAN SCI,TOKOROZAWA,SAITAMA 359,JAPAN
[3] NATL INST NEUROSCI,NCNP,DEPT NEUROMUSCULAR RES,KODAIRA,TOKYO 187,JAPAN
[4] JICHI MED SCH,DEPT PEDIAT,YAKUSHIJI,TOCHIGI 32908,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 232卷 / 01期
关键词：
D O I：
10.1006/bbrc.1997.6234
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
P19EC cells undergoes apoptosis during neuronal differentiation induced by retinoic acid. Two CPP32-like proteases, CPP32 and Mch-3, are expressed in untreated and retinoic acid-treated P19 EC cells. CPP32-like activity is remarkably increased in apoptosis during neuronal differentiation of P19 EC cells. Inhibition of CPP32-like proteases prevents apoptosis, suggesting that activation of CPP32-like proteases play central roles in the apoptosis during neuronal differentiation of P19 EC cells. Wortmannin, PI-3K inhibitor, enhances the CPP32-like activity of the retinoic acid-treated P19 EC cells. PI-3K may be involved in the apoptosis during neuronal differentiation as negative regulator. (C) 1997 Academic Press.
引用
收藏
页码：192 / 197
页数：6
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