Large-Scale Comparative Analyses of Tick Genomes Elucidate Their Genetic Diversity and Vector Capacities

被引：188

作者：

Jia, Na ^{[1
,28
]}

Wang, Jinfeng ^{[2
,5
]}

Shi, Wenqiang ^{[1
]}

Du, Lifeng ^{[2
,4
]}

Sun, Yi ^{[1
]}

Zhan, Wei ^{[3
]}

Jiang, Jia-Fu ^{[1
,28
]}

Wang, Qian ^{[1
,4
]}

Zhang, Bing ^{[2
]}

Ji, Peifeng ^{[2
]}

Bell-Sakyi, Lesley ^{[6
]}

Cui, Xiao-Ming ^{[1
,28
]}

Yuan, Ting-Ting ^{[1
]}

Jiang, Bao-Gui ^{[1
]}

Yang, Wei-Fei ^{[3
]}

Lam, Tommy Tsan-Yuk ^{[7
,8
]}

Chang, Qiao-Cheng ^{[9
]}

Ding, Shu-Jun ^{[10
]}

Wang, Xian-Jun ^{[10
]}

Zhu, Jin-Guo ^{[11
]}

Ruan, Xiang-Dong ^{[12
]}

Zhao, Lin ^{[1
,4
]}

Wei, Jia-Te ^{[1
,4
]}

Ye, Run-Ze ^{[1
,4
]}

Que, Teng Cheng ^{[13
]}

Du, Chun-Hong ^{[14
]}

Zhou, Yu-Hao ^{[1
]}

Cheng, Jing Xia ^{[15
]}

Dai, Pei-Fang ^{[15
]}

Guo, Wen-Bin ^{[1
]}

Han, Xiao-Hu ^{[16
]}

Huang, En-Jiong ^{[17
]}

Li, Lian-Feng ^{[1
]}

Wei, Wei ^{[1
]}

Gao, Yu-Chi ^{[3
]}

Liu, Jing-Ze ^{[18
]}

Shao, Hong-Ze ^{[19
]}

Wang, Xin ^{[20
]}

Wang, Chong-Cai ^{[21
]}

Yang, Tian-Ci ^{[22
]}

Huo, Qiu-Bo ^{[23
]}

Li, Wei ^{[24
]}

Chen, Hai-Ying ^{[25
]}

Chen, Shen-En ^{[25
]}

Zhou, Ling-Guo ^{[26
]}

Ni, Xue-Bing ^{[7
,8
]}

Tian, Jun-Hua ^{[27
]}

Sheng, Yue ^{[1
]}

Liu, Tao ^{[3
]}

Pan, Yu-Sheng ^{[1
]}

机构：

[1] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China

[2] Chinese Acad Sci, Beijing Inst Life Sci, Computat Genom Lab, Beijing 100101, Peoples R China

[3] Annord Gene Technol Beijing Co Ltd, Beijing 100176, Peoples R China

[4] Shandong Univ, Sch Publ Hlth, Inst EcoHlth, 44 Wenhuaxi St, Jinan 250012, Shandong, Peoples R China

[5] Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100101, Peoples R China

[6] Univ Liverpool, Inst Infect Ecol & Vet Sci, Dept Infect Biol & Microbiomes, Liverpool L3 5RF, Merseyside, England

[7] Univ Hong Kong, State Key Lab Emerging Infect Dis, Sch Publ Hlth, Hong Kong, Peoples R China

[8] Univ Hong Kong, Ctr Influenza Res, Sch Publ Hlth, Hong Kong, Peoples R China

[9] Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Daqing 163319, Heilongjiang, Peoples R China

[10] Shandong Ctr Dis Control & Prevent, Shandong Prov Key Lab Communicable Dis Control &, Jinan 250014, Shandong, Peoples R China

[11] ManZhouLi Customs Dist, Manzhouli 021400, Inner Mongolia, Peoples R China

[12] State Forestry & Grassland Adm, Acad Forest Inventory & Planning, Beijing 100714, Peoples R China

[13] Guangxi Zhuang Autonomous Reg Terr Wildlife Med A, Nanjing 530028, Guangxi, Peoples R China

[14] Yunnan Inst Endem Dis Control & Prevent, Dali 671000, Yunnan, Peoples R China

[15] Shanxi Provence Ctr Dis Control & Prevent, Xian 030012, Shanxi, Peoples R China

[16] Shenyang Agr Univ, Shenyang 110866, Liaoning, Peoples R China

[17] Fuzhou Int Travel Healthcare Ctr, Fuzhou 350001, Fujian, Peoples R China

[18] Hebei Normal Univ, Coll Life Sci, Key Lab Anim Physiol Biochem & Mol Biol Hebei Pro, Shijiazhuang 050024, Hebei, Peoples R China

[19] Anim Husb & Vet Sci Res Inst Jilin Prov, Changchun 130062, Jilin, Peoples R China

[20] Qingjiangpu Dist Ctr Dis Control & Prevent, Huaian 223001, Jiangsu, Peoples R China

[21] Hainan Int Travel Healthcare Ctr, Haikou 570311, Hainan, Peoples R China

[22] Hangzhou Customs China, State Key Lab Mosquito Borne Dis, Hangzhou Int Tourism Healthcare Ctr, Hangzhou 310012, Zhejiang, Peoples R China

[23] Mudanjiang Forestry Cent Hosp, Mudanjiang 157000, Heilongjiang, Peoples R China

[24] Xinjiang Ctr Dis Control & Prevent, Urumqi 830002, Xinjiang, Peoples R China

[25] Nanchang Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Collaborat Unit Field Epidemiol, Nanchang 330038, Jiangxi, Peoples R China

[26] Shaanxi Nat Reserve & Wildlife Adm Stn, Xian 710082, Shaanxi, Peoples R China

[27] Wuhan Ctr Dis Control & Prevent, Wuhan 430015, Hubei, Peoples R China

[28] Chinese Acad Med Sci, Res Unit Discovery & Tracing Nat Focus Dis, Beijing 100071, Peoples R China

[29] Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China

[30] Chinese Acad Sci, Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Biol, Hangzhou, Zhejiang, Peoples R China

[31] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

CELL | 2020年 / 182卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

ANAPLASMA-PHAGOCYTOPHILUM; IRON-METABOLISM; HUMAN INFECTION; READ ALIGNMENT; SEQUENCE; ACCURATE; PATHWAY; DISEASE; CHINA; HEME;

D O I：

10.1016/j.cell.2020.07.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Among arthropod vectors, ticks transmit the most diverse human and animal pathogens, leading to an increasing number of new challenges worldwide. Here we sequenced and assembled high-quality genomes of six ixodid tick species and further resequenced 678 tick specimens to understand three key aspects of ticks: genetic diversity, population structure, and pathogen distribution. We explored the genetic basis common to ticks, including heme and hemoglobin digestion, iron metabolism, and reactive oxygen species, and unveiled for the first time that genetic structure and pathogen composition in different tick species are mainly shaped by ecological and geographic factors. We further identified species-specific determinants associated with different host ranges, life cycles, and distributions. The findings of this study are an invaluable resource for research and control of ticks and tick-borne diseases.

引用

页码：1328 / +

页数：26

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