Regulatory B cells and tolerance in transplantation: from animal models to human

被引：54
作者：
Chesneau, Melanie [1 ,2 ]
Michel, Laure [1 ,3 ]
Degauque, Nicolas [1 ]
Brouard, Sophie [1 ,2 ,3 ]
机构：
[1] INSERM, U1064, Inst Transplantat Urol Nephrol, F-44093 Nantes 01, France
[2] Univ Nantes, Nantes, France
[3] CHU Nantes, F-44035 Nantes 01, France
来源：
FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷
关键词：
transplantation; regulatory B cells; animal; human; treatment; tolerance;
D O I：
10.3389/fimmu.2013.00497
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Until recently, the role of B cells in transplantation was thought to be restricted to producing antibodies that have been clearly shown to be deleterious in the long-term, but, in fact, B cells are also able to produce cytokine and to present antigen. Their role as regulatory cells in various pathological situations has also been highlighted, and their role in transplantation is beginning to emerge in animal, and also in human, models. This review summarizes the different studies in animals and humans that suggest a B-cell regulatory role in the transplant tolerance mechanisms.
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页数：8
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