Regulatory B cells and tolerance in transplantation: from animal models to human

被引：55

作者：

Chesneau, Melanie ^{[1
,2
]}

Michel, Laure ^{[1
,3
]}

Degauque, Nicolas ^{[1
]}

Brouard, Sophie ^{[1
,2
,3
]}

机构：

[1] INSERM, U1064, Inst Transplantat Urol Nephrol, F-44093 Nantes 01, France

[2] Univ Nantes, Nantes, France

[3] CHU Nantes, F-44035 Nantes 01, France

来源：

FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷

关键词：

transplantation; regulatory B cells; animal; human; treatment; tolerance;

D O I：

10.3389/fimmu.2013.00497

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Until recently, the role of B cells in transplantation was thought to be restricted to producing antibodies that have been clearly shown to be deleterious in the long-term, but, in fact, B cells are also able to produce cytokine and to present antigen. Their role as regulatory cells in various pathological situations has also been highlighted, and their role in transplantation is beginning to emerge in animal, and also in human, models. This review summarizes the different studies in animals and humans that suggest a B-cell regulatory role in the transplant tolerance mechanisms.

引用

页数：8

共 65 条

[1] BANK negatively regulates Akt activation and subsequent B cell responses [J].

Aiba, Y ;

Yamazaki, T ;

Okada, T ;

Gotoh, K ;

Sanjo, H ;

Ogata, M ;

Kurosaki, T .

IMMUNITY, 2006, 24 (03) :259-268

[2]

[Anonymous], 2011, BLOOD, DOI DOI 10.1182/BL00

[3] CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients [J].

Blair, Paul A. ;

Norena, Lina Yassin ;

Flores-Borja, Fabian ;

Rawlings, David J. ;

Isenberg, David A. ;

Ehrenstein, Michael R. ;

Mauri, Claudia .

IMMUNITY, 2010, 32 (01) :129-140

[4] Selective Targeting of B Cells with Agonistic Anti-CD40 Is an Efficacious Strategy for the Generation of Induced Regulatory T2-Like B Cells and for the Suppression of Lupus in MRL/lpr Mice [J].

Blair, Paul A. ;

Chavez-Rueda, Karina A. ;

Evans, Jamie G. ;

Shlomchik, Mark J. ;

Eddaoudi, Ayad ;

Isenberg, David A. ;

Ehrenstein, Michael R. ;

Mauri, Claudia .

JOURNAL OF IMMUNOLOGY, 2009, 182 (06) :3492-3502

[5] Regulatory B cells as inhibitors of immune responses and inflammation [J].

Bouaziz, Jean-David ;

Yanaba, Koichi ;

Tedder, Thomas F. .

IMMUNOLOGICAL REVIEWS, 2008, 224 :201-214

[6] The Natural History of Clinical Operational Tolerance After Kidney Transplantation Through Twenty-Seven Cases [J].

Brouard, S. ;

Pallier, A. ;

Renaudin, K. ;

Foucher, Y. ;

Danger, R. ;

Devys, A. ;

Cesbron, A. ;

Guillot-Guegen, C. ;

Ashton-Chess, J. ;

Le Roux, S. ;

Harb, J. ;

Roussey, G. ;

Subra, J. -F. ;

Villemain, F. ;

Legendre, C. ;

Bemelman, F. J. ;

Orlando, G. ;

Garnier, A. ;

Jambon, H. ;

De Sagazan, H. Le Monies ;

Braun, L. ;

Noel, C. ;

Pillebout, E. ;

Moal, M. -C. ;

Cantarell, C. ;

Hoitsma, A. ;

Ranbant, M. ;

Testa, A. ;

Soulillou, J. -P. ;

Giral, M. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2012, 12 (12) :3296-3307

[7] Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance [J].

Brouard, Sophie ;

Mansfield, Elaine ;

Braud, Christophe ;

Li, Li ;

Giral, Magali ;

Hsieh, Szu-Chuan ;

Baeten, Dominique ;

Zhang, Meixia ;

Ashton-Chess, Joanna ;

Braudeau, Cecile ;

Hsieh, Frank ;

Dupont, Alexandre ;

Pallier, Annaik ;

Moreau, Anne ;

Louis, Stephanie ;

Ruiz, Catherine ;

Salvatierra, Oscar ;

Soulillou, Jean-Paul ;

Sarwal, Minnie .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (39) :15448-15453

[8] Mice Lacking Endogenous IL-10-Producing Regulatory B Cells Develop Exacerbated Disease and Present with an Increased Frequency of Th1/Th17 but a Decrease in Regulatory T Cells [J].

Carter, Natalie A. ;

Vasconcellos, Rita ;

Rosser, Elizabeth C. ;

Tulone, Calogero ;

Munoz-Suano, Alba ;

Kamanaka, Masahito ;

Ehrenstein, Michael R. ;

Flavell, Richard A. ;

Mauri, Claudia .

JOURNAL OF IMMUNOLOGY, 2011, 186 (10) :5569-5579

[9] Unique B Cell Differentiation Profile in Tolerant Kidney Transplant Patients [J].

Chesneau, M. ;

Pallier, A. ;

Braza, F. ;

Lacombe, G. ;

Le Gallou, S. ;

Baron, D. ;

Giral, M. ;

Danger, R. ;

Guerif, P. ;

Aubert-Wastiaux, H. ;

Neel, A. ;

Michel, L. ;

Laplaud, D. -A. ;

Degauque, N. ;

Soulillou, J. -P. ;

Tarte, K. ;

Brouard, S. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 (01) :144-155

[10] Targeting B Cells and Antibody in Transplantation [J].

Clatworthy, M. R. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2011, 11 (07) :1359-1367

← 1 2 3 4 5 6 7 →