A fatal case of 3,4-methylenedioxypyrovalerone poisoning: coexistence of α-pyrrolidinobutiophenone and α-pyrrolidinovalerophenone in blood and/or hair

被引：58

作者：

Namera, Akira ^{[1
]}

Urabe, Shumari ^{[1
]}

Saito, Takeshi ^{[2
]}

Torikoshi-Hatano, Aiko ^{[1
]}

Shiraishi, Hiroaki ^{[1
]}

Arima, Yousuke ^{[1
]}

Nagao, Masataka ^{[1
]}

机构：

[1] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Forens Med, Minami Ku, Hiroshima 7348553, Japan

[2] Tokai Univ, Sch Med, Dept Emergency & Crit Care Med, Isehara, Kanagawa 25911, Japan

来源：

FORENSIC TOXICOLOGY | 2013年 / 31卷 / 02期

关键词：

3,4-Methylenedioxypyrovalerone (MDPV); alpha-Pyrrolidinovalerophenone (alpha-PVP); alpha-Pyrrolidinobutiophenone (alpha-PBP); Fatal poisoning; Blood level; Hair analysis; BATH SALTS; SYNTHETIC CATHINONES; DESIGNER DRUG; LEGAL HIGHS; METHAMPHETAMINE; AMPHETAMINE; CHROMATOGRAPHY; INTOXICATION; PHARMACOLOGY; PERFORMANCE;

D O I：

10.1007/s11419-013-0192-7

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

We report a fatal case of 3,4-methylenedioxypyrovalerone (MDPV) poisoning. A 35-year-old woman was taken to a nearby hospital after she was found unconscious. MDPV (1,200 ng/ml) and alpha-pyrrolidinobutiophenone (alpha-PBP; 200 ng/ml) were detected in her cardiac blood. Hair segments from the victim were also analyzed to confirm chronic drug use. MDPV and alpha-pyrrolidinovalerophenone (alpha-PVP) were found in many of the segments tested with the highest MDPV concentration at 22 ng/10-mm hair. We concluded that the woman died of acute MDPV poisoning, and that she had abused MDPV and alpha-PVP for a long time. To our knowledge, this is the first report dealing with MDPV in human hair segments, and with alpha-PBP in human specimens.

引用

页码：338 / 343

页数：6

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