Comparative study between oral miltefosine and parenteral N-metil glucamine antimoniate for the treatment of experimental leishmaniasis caused Leishmania (Leishmania) amazonensis

被引：20

作者：

da Costa Filho, Arnoldo Velloso ^{[1
]}

Lucas, Iris Campos ^{[1
]}

Ribeiro Sampaio, Raimunda Nonata ^{[1
]}

机构：

[1] Univ Brasilia, Lab Dermatomicol, Brasilia, DF, Brazil

来源：

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2008年 / 41卷 / 04期

关键词：

Miltefosine; Cutaneous leishmaniasis; Therapy;

D O I：

10.1590/S0037-86822008000400022

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Twenty-five mice were infected with Leishmania amazonensis and treated with glucamine and oral miltefosine. The criteria used were pad measurements and investigations of amastigotes and cultures after treatment. Measurements: miltefosine 2.43 mm and glucamine 3.46 mm (p: 0.05). Miltefosine smears and cultures were negative. Glucamine produced two positive smears and the cultures were positive (p < 0.05). Miltefosine was similar to or better than glucamine.

引用

页码：424 / 427

页数：4

共 22 条

[1] RECURRENT CUTANEOUS LEISHMANIASIS - A ROLE FOR PERSISTENT PARASITES
AEBISCHER, T
[J]. PARASITOLOGY TODAY, 1994, 10 (01): : 25 - 28
[2] Decrease of intestinal P-glycoprotein activity by 2n-propylquinoline, a new oral treatment for visceral leishmaniasis
Belliard, AM
Leroy, C
Banide, H
Farinotti, R
Lacour, B
[J]. EXPERIMENTAL PARASITOLOGY, 2003, 103 (1-2) : 51 - 56
[3] THE ACTIVITY OF ALKYL PHOSPHORYLCHOLINES AND RELATED DERIVATIVES AGAINST LEISHMANIA-DONOVANI
CROFT, SL
NEAL, RA
PENDERGAST, W
CHAN, JH
[J]. BIOCHEMICAL PHARMACOLOGY, 1987, 36 (16) : 2633 - 2636
[4] PRESENCE OF LEISHMANIA-BRAZILIENSIS IN BLOOD-SAMPLES FROM CURED PATIENTS OR AT DIFFERENT STAGES OF IMMUNOTHERAPY
GUEVARA, P
ROJAS, E
GONZALEZ, N
SCORZA, JV
ANEZ, N
VALERA, M
RAMIREZ, JL
[J]. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1994, 1 (04) : 385 - 389
[5] HEXADECYLPHOSPHOCHOLINE - ORAL TREATMENT OF VISCERAL LEISHMANIASIS IN MICE
KUHLENCORD, A
MANIERA, T
EIBL, H
UNGER, C
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (08) : 1630 - 1634
[6] A simple method for quantifying Leishmania in tissues of infected animals
Lima, HC
Bleyenberg, JA
Titus, RG
[J]. PARASITOLOGY TODAY, 1997, 13 (02): : 80 - 82
[7] Comparison of miltefosine and meglumine antimoniate for the treatment of zoonotic cutaneous leishmaniasis (ZCL) by a randomized clinical trial in Iran
Mohebali, M.
Fotouhi, A.
Hooshmand, B.
Zarei, Z.
Akhoundi, B.
Rahnema, A.
Razaghian, A. R.
Kabir, M. J.
Nadim, A.
[J]. ACTA TROPICA, 2007, 103 (01) : 33 - 40
[8] More B, 2003, J Postgrad Med, V49, P101
[9] Suppression of posttreatment recurrence of experimental visceral leishmaniasis in T-cell-deficient mice by oral miltefosine
Murray, HW
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (11) : 3235 - 3236
[10] Visceral leishmanicidal activity of hexadecylphosphocholine (miltefosine) in mice deficient in T cells and activated macrophage microbicidal mechanisms
Murray, HW
Delph-Etienne, S
[J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (02) : 795 - 799

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