Impact of prenatal ischemia on behavior, cognitive abilities and neuroanatomy in adult rats with white matter damage

被引：55

作者：

Delcour, Maxime ^{[2
,3
]}

Russier, Michael ^{[1
,2
,3
]}

Amin, Mamta ^{[4
]}

Baud, Olivier ^{[5
,6
]}

Paban, Veronique ^{[2
,3
]}

Barbe, Mary F. ^{[4
]}

Coq, Jacques-Olivier ^{[1
,2
,3
]}

机构：

[1] Aix Marseille Univ, INSERM, UMR Unite Neurobiol Canaux Lon & Synapse 1072, Fac Med,Sect Nord, F-13344 Marseille 15, France

[2] CNRS, UMR Neurosci Integrat & Adaptat 7260, F-13331 Marseille 03, France

[3] Aix Marseille Univ, F-13331 Marseille 03, France

[4] Temple Univ, Dept Anat & Cell Biol, Sch Med, Philadelphia, PA 19140 USA

[5] Univ Paris 07, INSERM, U676, Fac Med Denis Diderot, F-75019 Paris, France

[6] Hop Robert Debre, AP HP, F-75019 Paris, France

来源：

BEHAVIOURAL BRAIN RESEARCH | 2012年 / 232卷 / 01期

关键词：

Object recognition memory; Morris watermaze; Open-field activity; Perinatal hypoxia-ischemia; Prematurity; ADHD; MEDIAL PREFRONTAL CORTEX; BRAIN-INJURY; HYPOXIA-ISCHEMIA; OBJECT-RECOGNITION; SPATIAL MEMORY; ANIMAL-MODEL; SHORT-TERM; FUNCTIONAL DEFICITS; PERINATAL ASPHYXIA; EXECUTIVE FUNCTION;

D O I：

10.1016/j.bbr.2012.03.029

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Early brain damage, such as white matter damage (WMD), resulting from perinatal hypoxia-ischemia in preterm and low birth weight infants represents a high risk factor for mortality and chronic disabilities, including sensory, motor, behavioral and cognitive disorders. In previous studies, we developed a model of WMD based on prenatal ischemia (PI), induced by unilateral ligation of uterine artery at E17 in pregnant rats. We have shown that PI reproduced some of the main deficits observed in preterm infants, such as white and gray matter damage, myelination deficits, locomotor, sensorimotor, and short-term memory impairments, as well as related musculoskeletal and neuroanatomical histopathologies [1-3]. Here, we determined the deleterious impact of PI on several behavioral and cognitive abilities in adult rats, as well as on the neuroanatomical substratum in various related brain areas. Adult PI rats exhibited spontaneous exploratory and motor hyperactivity, deficits in information encoding, and deficits in short- and long-term object memory tasks, but no impairments in spatial learning or working memory in watermaze tasks. These results were in accordance with white matter injury and damage in the medial and lateral entorhinal cortices, as detected by axonal degeneration, astrogliosis and neuronal density. Although there was astrogliosis and axonal degeneration in the fornix, hippocampus and cingulate cortex, neuronal density in the hippocampus and cingulate cortex was not affected by PI. Levels of spontaneous hyperactivity, deficits in object memory tasks, neuronal density in the medial and lateral entorhinal cortices, and astrogliosis in the fornix correlated with birth weight in PI rats. Thus, this rodent model of WMD based on PI appears to recapitulate the main neurobehavioral and neuroanatomical human deficits often observed in preterm children with a perinatal history of ischemia. (C) 2012 Elsevier B.V. All rights reserved,

引用

页码：233 / 244

页数：12

共 67 条

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