Atypical chemokine receptors: emerging therapeutic targets in cancer

被引：27

作者：

Torphy, Robert J. ^{[1
]}

Yee, Elliott J. ^{[1
]}

Schulick, Richard D. ^{[1
]}

Zhu, Yuwen ^{[1
]}

机构：

[1] Univ Colorado, Dept Surg, Anschutz Med Campus, Aurora, CO 80045 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2022年 / 43卷 / 12期

关键词：

cell homing; Second; ACKR expression; CELLS; IDENTIFICATION; MIGRATION; CCRL2; RECRUITMENT; COMPLEMENT; CHEMERIN; CXCR7; GENES; DRUGS;

D O I：

10.1016/j.tips.2022.09.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Atypical chemokine receptors (ACKRs) regulate the availability of chemokines via chemokine scavenging, while also having the capacity to elicit downstream function through beta-arrestin coupling. This contrasts with conventional chemokine receptors that directly elicit immune cell migration through G protein-coupled signaling. The significance of ACKRs in cancer biology has previously been poorly understood, but recent findings have highlighted the multifaceted role of these receptors in tumorigenesis and immune response modulation within the tumor mi-croenvironment (TME). Additionally, recent research has expanded our understand-ing of the function of several receptors including GPR182, CCRL2, GPR1, PITPNM3, and C5aR2 that share similarities with the ACKR family. In this review, we discuss these recent developments, and highlight the opportunities and challenges of phar-macologically targeting ACKRs in cancer.

引用

页码：1085 / 1097

页数：13

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