Regulation of pannexin channels in the central nervous system by Src family kinases

被引：14

作者：

Lohman, Alexander W. ^{[1
,2
]}

Weilinger, Nicholas L. ^{[3
]}

Santos, Silva M. F. ^{[1
,2
]}

Bialecki, Jennifer ^{[1
,2
]}

Werner, Allison C. ^{[1
,2
]}

Anderson, Connor L. ^{[1
,2
]}

Thompson, Roger J. ^{[1
,2
]}

机构：

[1] Univ Calgary, Dept Cell Biol & Anat, Calgary, AB, Canada

[2] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada

[3] Univ British Columbia, Djavad Mowafaghian Ctr Brain Hlth, Fac Med, Vancouver, BC, Canada

来源：

NEUROSCIENCE LETTERS | 2019年 / 695卷

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

Pannexin; Src family kinase; Tyrosine phosphorylation; Central nervous system; PROTEIN-TYROSINE KINASES; NMDA RECEPTORS; ATP RELEASE; NITRIC-OXIDE; ACETYLCHOLINE-RECEPTOR; PHOSPHORYLATION SITES; SYNAPTIC PLASTICITY; PROBENECID PROTECTS; ASTROCYTES; EXPRESSION;

D O I：

10.1016/j.neulet.2017.09.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pannexins form single membrane channels that regulate the passage of ions, small molecules and metabolites between the intra- and extracellular compartments. In the central nervous system, these channels are integrated into numerous signaling cascades that shape brain physiology and pathology. Post-translational modification of pannexins is complex, with phosphorylation emerging as a prominent form of functional regulation. While much is still not known regarding the specific kinases and modified amino acids, recent reports support a role for Src family tyrosine kinases (SFK) in regulating pannexin channel activity. This review outlines the current evidence supporting SFK-dependent pannexin phosphorylation in the CNS and examines the importance of these modifications in the healthy and diseased brain.

引用

页码：65 / 70

页数：6

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