A new steroidal glycoside from the fruits ofSolanum myriacanthum

被引：5
|
作者：
Ono, Masateru [1 ]
Shimode, Mizuki [1 ]
Tsutsumi, Shuhei [1 ]
Yasuda, Shin [1 ]
Okawa, Masafumi [2 ]
Kinjo, Junei [2 ]
Miyashita, Hiroyuki [3 ]
Ikeda, Tsuyoshi [3 ]
Yoshimitsu, Hitoshi [3 ]
Nohara, Toshihiro [3 ]
机构：
[1] Tokai Univ, Sch Agr, Kumamoto, Japan
[2] Fukuoka Univ, Fac Pharmaceut Sci, Fukuoka, Japan
[3] Sojo Univ, Fac Pharmaceut Sci, Kumamoto, Japan
来源：
NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 01期
关键词：
Solanum myriacanthum; Solanaceae; cholestane-type steroidal glycoside; cytotoxic activity; C-13; NMR-SPECTROSCOPY; UNDERGROUND PARTS; TRILLIUM-ERECTUM; SAPONINS; ALKALOIDS; SHIFTS; CONSTITUENTS; AGLYCONE; PLANTS;
D O I：
10.1080/14786419.2020.1781117
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new cholestane-type steroidal glycoside, solamyriaside A (1), was isolated from the fruits ofSolanum myriacanthumDunal (Solanaceae), along with two known steroidal glycosides, namely, solaviaside A (2) and aculeatiside A (3), and three known steroidal alkaloid glycosides, namely, solamargine (4), khasianine (5) and solasonine (6), which were isolated for the first time from this plant. Based on spectroscopic data as well as chemical evidence,1was determined to be 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-O-[alpha-L-rhamnopyranosyl-(1 -> 4)]-beta-D-glucopyranosyl-22R,25R-cholest-5-ene-3 beta,16 alpha,22,26-tetraol 26-O-beta-D-glucopyranoside. The cytotoxic activity of1-6against HL-60 human promyelocytic leukaemia cells was examined. Compounds4-6showed cytotoxic activity. Among them,4exhibited the strongest activity with an IC(50)value of 4.64 +/- 0.17 mu M, similar to the activity of cisplatin, a positive control.
引用
收藏
页码：326 / 333
页数：8
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